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Select item 100577921.

Lens-specific βA3/A1-conditional knockout mice: Phenotypic characteristics and calpain activation causing protein degradation and insolubilization

Roy Joseph, Michael L. Robinson, Laura Lambert, Om P. Srivastava

PLoS One. 2023; 18(3): e0281386. Published online 2023 Mar 29. doi: 10.1371/journal.pone.0281386

PMCID:: PMC10057792

Article PDF–2.4M

Select item 60586942.

A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration

Sayan Ghosh, Peng Shang, Hiroto Terasaki, Nadezda Stepicheva, Stacey Hose, Meysam Yazdankhah, Joseph Weiss, Taiji Sakamoto, Imran A. Bhutto, Shuli Xia, J. Samuel Zigler, Jr, Ram Kannan, Jiang Qian, James T. Handa, Debasish Sinha

Invest Ophthalmol Vis Sci. 2018 Jul; 59(4): AMD104–AMD113. doi: 10.1167/iovs.18-24132

PMCID:: PMC6058694

Article PDF–1.3M

Select item 42681653.

βA3/A1-CRYSTALLIN: MORE THAN A LENS PROTEIN

J. Samuel Zigler, Jr., Debasish Sinha

Prog Retin Eye Res. Author manuscript; available in PMC 2016 Jan 1.

Published in final edited form as: Prog Retin Eye Res. 2015 Jan; 0: 62–85. Published online 2014 Nov 13. doi: 10.1016/j.preteyeres.2014.11.002

PMCID:: PMC4268165

Article PDF–4.9M

Select item 37739444.

βA3/A1-crystallin is required for proper astrocyte template formation and vascular remodeling in the retina

Debasish Sinha, Mallika Valapala, Imran Bhutto, Bonnie Patek, Cheng Zhang, Stacey Hose, Fang Yang, Marisol Cano, Walter J. Stark, Gerard A. Lutty, J. Samuel Zigler, Jr., Eric F. Wawrousek

Transgenic Res. Author manuscript; available in PMC 2013 Sep 16.

Published in final edited form as: Transgenic Res. 2012 Oct; 21(5): 1033–1042. Published online 2012 Mar 17. doi: 10.1007/s11248-012-9608-0

PMCID:: PMC3773944

Article PDF–1.4M

Select item 82668595.

βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells

Peng Shang, Nadezda Stepicheva, Kenneth Teel, Austin McCauley, Christopher Scott Fitting, Stacey Hose, Rhonda Grebe, Meysam Yazdankhah, Sayan Ghosh, Haitao Liu, Anastasia Strizhakova, Joseph Weiss, Imran A. Bhutto, Gerard A. Lutty, Ashwath Jayagopal, Jiang Qian, José-Alain Sahel, J. Samuel Zigler, Jr., James T. Handa, Yuri Sergeev, Raju V. S. Rajala, Simon Watkins, Debasish Sinha

Commun Biol. 2021; 4: 850. Published online 2021 Jul 8. doi: 10.1038/s42003-021-02386-6

PMCID:: PMC8266859

Article PDF–8.9M

Select item 67543816.

Neutrophils homing into the retina trigger pathology in early age-related macular degeneration

Sayan Ghosh, Archana Padmanabhan, Tanuja Vaidya, Alan M. Watson, Imran A. Bhutto, Stacey Hose, Peng Shang, Nadezda Stepicheva, Meysam Yazdankhah, Joseph Weiss, Manjula Das, Santosh Gopikrishna, Aishwarya, Naresh Yadav, Thorsten Berger, Tak W. Mak, Shuli Xia, Jiang Qian, Gerard A. Lutty, Ashwath Jayagopal, J. Samuel Zigler, Jr, Swaminathan Sethu, James T. Handa, Simon C. Watkins, Arkasubhra Ghosh, Debasish Sinha

Commun Biol. 2019; 2: 348. Published online 2019 Sep 20. doi: 10.1038/s42003-019-0588-y

PMCID:: PMC6754381

Article PDF–5.6M

Select item 53345317.

The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling

Peng Shang, Mallika Valapala, Rhonda Grebe, Stacey Hose, Sayan Ghosh, Imran A. Bhutto, James T. Handa, Gerard A. Lutty, Lixia Lu, Jun Wan, Jiang Qian, Yuri Sergeev, Rosa Puertollano, J. Samuel Zigler, Jr, Guo‐Tong Xu, Debasish Sinha

Aging Cell. 2017 Apr; 16(2): 349–359. Published online 2017 Jan 13. doi: 10.1111/acel.12561

PMCID:: PMC5334531

Article PDF–3.4M

Select item 48706038.

Human βA3/A1-crystallin splicing mutation causes cataracts by activating the unfolded protein response and inducing apoptosis in differentiating lens fiber cells

Zhiwei Ma, Wenliang Yao, Chi Chao Chan, Chitra Kannabiran, Eric Wawrousek, J. Fielding Hejtmancik

Biochim Biophys Acta. Author manuscript; available in PMC 2017 Jun 1.

Published in final edited form as: Biochim Biophys Acta. 2016 Jun; 1862(6): 1214–1227. Published online 2016 Feb 4. doi: 10.1016/j.bbadis.2016.02.003

PMCID:: PMC4870603

Article PDF–2.2M

Select item 47492109.

CRYβA3/A1-Crystallin Knockout Develops Nuclear Cataract and Causes Impaired Lysosomal Cargo Clearance and Calpain Activation

Shylaja Hegde, Robert A. Kesterson, Om P. Srivastava

PLoS One. 2016; 11(2): e0149027. Published online 2016 Feb 10. doi: 10.1371/journal.pone.0149027

PMCID:: PMC4749210

Article PDF–16M

Select item 424424910.

Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response

Mallika Valapala, Malia Edwards, Stacey Hose, Rhonda Grebe, Imran A Bhutto, Marisol Cano, Thorsten Berger, Tak W Mak, Eric Wawrousek, James T Handa, Gerard A Lutty, J Samuel Zigler, Debasish Sinha

Aging Cell. 2014 Dec; 13(6): 1091–1094. Published online 2014 Sep 25. doi: 10.1111/acel.12274

PMCID:: PMC4244249

Article PDF–805K

Select item 222816211.

The effect of hypoxia and hyperoxia on nucleoside triphosphate/inorganic phosphate, pO2 and radiation response in an experimental tumour model.

M. Nordsmark, R. J. Maxwell, M. R. Horsman, S. M. Bentzen, J. Overgaard

Br J Cancer. 1997; 76(11): 1432–1439. doi: 10.1038/bjc.1997.575

PMCID:: PMC2228162

Summary Page Browse PDF–1.3M

Select item 790495412.

βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity

Sayan Ghosh, Haitao Liu, Meysam Yazdankhah, Nadezda Stepicheva, Peng Shang, Tanuja Vaidya, Stacey Hose, Urvi Gupta, Michael Joseph Calderon, Ming-Wen Hu, Archana Padmanabhan Nair, Joseph Weiss, Christopher S. Fitting, Imran A. Bhutto, Santosh Gopi Krishna Gadde, Naveen Kumar Naik, Chaitra Jaydev, Gerard A. Lutty, James T. Handa, Ashwath Jayagopal, Jiang Qian, José-Alain Sahel, Dhivyaa Rajasundaram, Yuri Sergeev, J. Samuel Zigler, Jr., Swaminathan Sethu, Simon Watkins, Arkasubhra Ghosh, Debasish Sinha

Commun Biol. 2021; 4: 248. Published online 2021 Feb 24. doi: 10.1038/s42003-021-01763-5

PMCID:: PMC7904954

Article PDF–12M

Select item 407788613.

Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling

Mallika Valapala, Christine Wilson, Stacey Hose, Imran A Bhutto, Rhonda Grebe, Aling Dong, Seth Greenbaum, Limin Gu, Samhita Sengupta, Marisol Cano, Sean Hackett, Guotong Xu, Gerard A Lutty, Lijin Dong, Yuri Sergeev, James T Handa, Peter Campochiaro, Eric Wawrousek, J Samuel Zigler, Jr, Debasish Sinha

Autophagy. 2014 Mar 1; 10(3): 480–496. Published online 2014 Jan 23. doi: 10.4161/auto.27292

PMCID:: PMC4077886

Article PDF–4.2M

Select item 371802914.

Impaired endolysosomal function disrupts Notch signaling in optic nerve astrocytes

Mallika Valapala, Stacey Hose, Celine Gongora, Lijin Dong, Eric F. Wawrousek, J. Samuel Zigler, Jr., Debasish Sinha

Nat Commun. Author manuscript; available in PMC 2013 Jul 22.

Published in final edited form as: Nat Commun. 2013; 4: 1629. doi: 10.1038/ncomms2624

PMCID:: PMC3718029

Article PDF–2.5M

Select item 300371215.

Physiological expression of lens α-, β-, and γ-crystallins in murine and human corneas

Shengwei Ren, Ting Liu, Changkai Jia, Xia Qi, Yiqiang Wang

Mol Vis. 2010; 16: 2745–2752. Published online 2010 Dec 15.

PMCID:: PMC3003712

Article PDF–719K

Select item 211952916.

Expression of the murine small heat shock proteins hsp 25 and alpha B crystallin in the absence of stress

J Cell Biol. 1993 Feb 1; 120(3): 639–645. doi: 10.1083/jcb.120.3.639

PMCID:: PMC2119529

Summary PDF–1.0M

Select item 535719017.

Activating the AKT2/NF B/LCN-2 axis elicits an inflammatory response in age-related macular degeneration: Lipocalin-2 as an indicator of early AMD

Sayan Ghosh, Peng Shang, Meysam Yazdankhah, Imran Bhutto, Stacey Hose, Sandra R Montezuma, Tianqi Luo, Sreya Chattopadhyay, Jiang Qian, Gerard A Lutty, Deborah A Ferrington, J. Samuel Zigler, Jr., Debasish Sinha

J Pathol. Author manuscript; available in PMC 2018 Apr 1.

Published in final edited form as: J Pathol. 2017 Apr; 241(5): 583–588. Published online 2017 Feb 20. doi: 10.1002/path.4870

PMCID:: PMC5357190

Article PDF–544K

Select item 434862818.

βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes

Mallika Valapala, Malia Edwards, Stacey Hose, Jianfei Hu, Eric Wawrousek, Gerard A. Lutty, J. Samuel Zigler, Jr., Jiang Qian, Debasish Sinha

Sci Rep. 2015; 5: 8755. Published online 2015 Mar 4. doi: 10.1038/srep08755

PMCID:: PMC4348628

Article PDF–5.6M

Select item 610991819.

Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process

Saima Limi, Adrien Senecal, Robert Coleman, Melissa Lopez-Jones, Peng Guo, Christina Polumbo, Robert H. Singer, Arthur I. Skoultchi, Ales Cvekl

J Biol Chem. 2018 Aug 24; 293(34): 13176–13190. Published online 2018 Jun 29. doi: 10.1074/jbc.RA118.001927

PMCID:: PMC6109918

Article PDF–4.1M

Select item 39814020.

Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo.

S D Morgenbesser, N Schreiber-Agus, M Bidder, K A Mahon, P A Overbeek, J Horner, R A DePinho

EMBO J. 1995 Feb 15; 14(4): 743–756. doi: 10.1002/j.1460-2075.1995.tb07053.x

PMCID:: PMC398140

Summary Page Browse PDF–4.3M

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