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Items: 1 to 20 of 68

1.
TREX1 531C/T Polymorphism and Autoantibodies Associated with the Immune Status of HIV-1-Infected Individuals
Maria Alice Freitas Queiroz, Tuane Carolina Ferreira Moura, Carlos David Araújo Bichara, Lorena Leticia Peixoto de Lima, Allysson Quintino Tenório de Oliveira, Ranilda Gama de Souza, Samara Tatielle Monteiro Gomes, Ednelza da Silva Graça Amoras, Antonio Carlos Rosário Vallinoto
Int J Mol Sci. 2023 Jun; 24(11): 9660. Published online 2023 Jun 2. doi: 10.3390/ijms24119660
PMCID:
PMC10253649
ArticlePDF–2.6M
2.
Structural basis of human TREX1 DNA degradation and autoimmune disease
Wen Zhou, Desmond Richmond-Buccola, Qiannan Wang, Philip J. Kranzusch
Nat Commun. 2022; 13: 4277. Published online 2022 Jul 25. doi: 10.1038/s41467-022-32055-z
PMCID:
PMC9314330
ArticlePDF–1.8M
3.
TREX1 degrades the 3′ end of the small DNA oligonucleotide products of nucleotide excision repair in human cells
Seon Hee Kim, Geun Hoe Kim, Michael G Kemp, Jun-Hyuk Choi
Nucleic Acids Res. 2022 Apr 22; 50(7): 3974–3984. Published online 2022 Mar 31. doi: 10.1093/nar/gkac214
PMCID:
PMC9023299
ArticlePDF–3.8M
4.
Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases
Jin Hu, Liudi Tang, Junjun Cheng, Tianlun Zhou, Yuhuan Li, Jinhong Chang, Qiong Zhao, Ju-Tao Guo
Emerg Microbes Infect. 2021; 10(1): 852–864. Published online 2021 May 1. doi: 10.1080/22221751.2021.1919034
PMCID:
PMC8812769
ArticlePDF–1.7M
5.
TREX1 as a Novel Immunotherapeutic Target
Wayne O. Hemphill, Sean R. Simpson, Mingyong Liu, Freddie R. Salsbury, Jr, Thomas Hollis, Jason M. Grayson, Fred W. Perrino
Front Immunol. 2021; 12: 660184. Published online 2021 Apr 1. doi: 10.3389/fimmu.2021.660184
PMCID:
PMC8047136
ArticlePDF–3.2M
6.
TREX1 – Apex predator of cytosolic DNA metabolism
Sean R. Simpson, Wayne O. Hemphill, Teesha Hudson, Fred W. Perrino
DNA Repair (Amst) Author manuscript; available in PMC 2021 Mar 23.
Published in final edited form as: DNA Repair (Amst). 2020 Oct; 94: 102894. Published online 2020 Jun 12. doi: 10.1016/j.dnarep.2020.102894
PMCID:
PMC7985832
ArticlePDF–1.1M
7.
Epigenome-wide DNA methylation analysis of small cell lung cancer cell lines suggests potential chemotherapy targets
Julia Krushkal, Thomas Silvers, William C. Reinhold, Dmitriy Sonkin, Suleyman Vural, John Connelly, Sudhir Varma, Paul S. Meltzer, Mark Kunkel, Annamaria Rapisarda, David Evans, Yves Pommier, Beverly A. Teicher
Clin Epigenetics. 2020; 12: 93. Published online 2020 Jun 25. doi: 10.1186/s13148-020-00876-8
PMCID:
PMC7318526
ArticlePDF–1.6M
8.
Familial chilblain lupus due to a novel mutation in TREX1 associated with Aicardi–Goutie’res syndrome
Cuili Yi, Qiyuan Li, Jihong Xiao
Pediatr Rheumatol Online J. 2020; 18: 32. Published online 2020 Apr 15. doi: 10.1186/s12969-020-00423-y
PMCID:
PMC7158086
ArticlePDF–6.2M
9.
TREX1 531C>T Polymorphism is Associated with High Proviral Load Levels in HTLV-1-Infected Persons
Denis de Castro Silva, Ednelza da Silva Graça Amoras, Tuane Carolina Ferreira Moura, Felipe Teixeira Lopes, Samara Tatielle Monteiro Gomes, Carlos A. da Costa, Maísa Silva Sousa, Ricardo Ishak, Antonio Carlos Rosário Vallinoto, Maria Alice Freitas Queiroz
Viruses. 2020 Jan; 12(1): 7. Published online 2019 Dec 19. doi: 10.3390/v12010007
PMCID:
PMC7019804
ArticlePDF–1.8M
10.
TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia
Parul H. Kothari, Grant R. Kolar, Joanna C. Jen, Rula Hajj‐Ali, Paula Bertram, Robert E. Schmidt, John P. Atkinson
Brain Pathol. 2018 Nov; 28(6): 806–821. Published online 2018 Oct 10. doi: 10.1111/bpa.12626
PMCID:
PMC6404532
ArticlePDF–1.2M
11.
Three Prime Repair Exonuclease 1 (TREX1) expression correlates with cervical cancer cells growth in vitro and disease progression in vivo
Bruna Prati, Walason da Silva Abjaude, Lara Termini, Mirian Morale, Suellen Herbster, Adhemar Longatto-Filho, Rafaella Almeida Lima Nunes, Lizeth Carolina Córdoba Camacho, Silvia Helena Rabelo-Santos, Luiz Carlos Zeferino, Francisco Aguayo, Enrique Boccardo
Sci Rep. 2019; 9: 351. Published online 2019 Jan 23. doi: 10.1038/s41598-018-37064-x
PMCID:
PMC6344518
ArticlePDF–2.0M
12.
Modeling of TREX1-dependent autoimmune disease using human stem cells highlights L1 accumulation as a source of neuroinflammation
Charles A. Thomas, Leon Tejwani, Cleber A. Trujillo, Priscilla D. Negraes, Roberto H. Herai, Pinar Mesci, Angela Macia, Yanick J. Crow, Alysson R. Muotri
Cell Stem Cell. Author manuscript; available in PMC 2018 Sep 7.
Published in final edited form as: Cell Stem Cell. 2017 Sep 7; 21(3): 319–331.e8. Published online 2017 Aug 10. doi: 10.1016/j.stem.2017.07.009
PMCID:
PMC5591075
ArticlePDF–2.8M
13.
DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice
Tomomi Sakai, Takuya Miyazaki, Dong-Mi Shin, Yong-Soo Kim, Chen-Feng Qi, Robert Fariss, Jeeva Munasinghe, Hongsheng Wang, Alexander L. Kovalchuk, Parul H. Kothari, Charles S. Fermaintt, John P. Atkinson, Fred W. Perrino, Nan Yan, Herbert C. Morse, III
J Autoimmun. Author manuscript; available in PMC 2017 Aug 16.
Published in final edited form as: J Autoimmun. 2017 Jul; 81: 13–23. Published online 2017 Mar 18. doi: 10.1016/j.jaut.2017.03.001
PMCID:
PMC5558601
ArticlePDF–2.5M
14.
A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1
Erkin Erdal, Syed Haider, Jan Rehwinkel, Adrian L. Harris, Peter J. McHugh
Genes Dev. 2017 Feb 15; 31(4): 353–369. doi: 10.1101/gad.289769.116
PMCID:
PMC5358756
ArticlePDF–2.7M
15.
MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment
RaeAnna Wilson, Cristina Espinosa-Diez, Nathan Kanner, Namita Chatterjee, Rebecca Ruhl, Christina Hipfinger, Sunil J. Advani, Jie Li, Omar F. Khan, Aleksandra Franovic, Sara M. Weis, Sushil Kumar, Lisa M. Coussens, Daniel G. Anderson, Clark C. Chen, David A. Cheresh, Sudarshan Anand
Nat Commun. 2016; 7: 13597. Published online 2016 Nov 25. doi: 10.1038/ncomms13597
PMCID:
PMC5133658
ArticlePDF–1.3M
16.
Verification of TREX1 as a promising indicator of judging the prognosis of osteosarcoma
Jinyi Feng, Ruilong Lan, Guanxiong Cai, Jinluan Lin, Xinwen Wang, Jianhua Lin, Deping Han
J Orthop Surg Res. 2016; 11: 150. Published online 2016 Nov 24. doi: 10.1186/s13018-016-0487-6
PMCID:
PMC5122164
ArticlePDF–2.2M
17.
The Arg-62 Residues of the TREX1 Exonuclease Act Across the Dimer Interface Contributing to Catalysis in the Opposing Protomers
Jason M. Fye, Stephanie R. Coffin, Clinton D. Orebaugh, Thomas Hollis, Fred W. Perrino
J Biol Chem. 2014 Apr 18; 289(16): 11556–11565. Published online 2014 Mar 9. doi: 10.1074/jbc.M114.559252
PMCID:
PMC4036290
ArticlePDF–1.9M
18.
Rare Variants in the TREX1 Gene and Susceptibility to Autoimmune Diseases
Nadia Barizzone, Sara Monti, Simona Mellone, Michela Godi, Maurizio Marchini, Raffaella Scorza, Maria G. Danieli, Sandra D'Alfonso
Biomed Res Int. 2013; 2013: 471703. Published online 2013 Oct 9. doi: 10.1155/2013/471703
PMCID:
PMC3810194
ArticlePDF–613K
19.
TREX1 acts in degrading damaged DNA from drug-treated tumor cells
Chuan-Jen Wang, Wing Lam, Scott Bussom, Hua-Mei Chang, Yung-Chi Cheng
DNA Repair (Amst) Author manuscript; available in PMC 2013 May 1.
Published in final edited form as: DNA Repair (Amst). 2009 Oct 2; 8(10): 1179–1189. Published online 2009 Jul 18. doi: 10.1016/j.dnarep.2009.06.006
PMCID:
PMC3640554
ArticlePDF–3.6M
20.
The TREX1 Exonuclease R114H Mutation in Aicardi-Goutières Syndrome and Lupus Reveals Dimeric Structure Requirements for DNA Degradation Activity
Clinton D. Orebaugh, Jason M. Fye, Scott Harvey, Thomas Hollis, Fred W. Perrino
J Biol Chem. 2011 Nov 18; 286(46): 40246–40254. Published online 2011 Sep 21. doi: 10.1074/jbc.M111.297903
PMCID:
PMC3220555
ArticlePDF–3.4M

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