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Select item 99568891.

Ablation of Gabra5 Influences Corticosterone Levels and Anxiety-like Behavior in Mice

Linn Amanda Syding, Agnieszka Kubik-Zahorodna, David Pajuelo Reguera, Petr Nickl, Bohdana Hruskova, Michaela Kralikova, Jana Kopkanova, Vendula Novosadova, Petr Kasparek, Jan Prochazka, Jan Rozman, Rostislav Turecek, Radislav Sedlacek

Genes (Basel) 2023 Feb; 14(2): 285. Published online 2023 Jan 21. doi: 10.3390/genes14020285

PMCID:: PMC9956889

Article PDF–2.9M

Select item 94713802.

Gabra5 plays a sexually dimorphic role in POMC neuron activity and glucose balance

Zhou Pei, Yang He, Jonathan C. Bean, Yongjie Yang, Hailan Liu, Meng Yu, Kaifan Yu, Ilirjana Hyseni, Xing Cai, Hesong Liu, Na Qu, Longlong Tu, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Na Yin, Nan Zhang, Junying Han, Camille HS. Potts, Nikolas A. Scarcelli, Zili Yan, Pingwen Xu, Qi Wu, Yanlin He, Yong Xu, Chunmei Wang

Front Endocrinol (Lausanne) 2022; 13: 889122. Published online 2022 Aug 31. doi: 10.3389/fendo.2022.889122

PMCID:: PMC9471380

Article PDF–4.8M

Select item 77863633.

Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation

Thomas D Prevot, Akiko Sumitomo, Toshifumi Tomoda, Daniel E Knutson, Guanguan Li, Prithu Mondal, Mounira Banasr, James M Cook, Etienne Sibille

Cereb Cortex. 2021 Feb; 31(2): 1395–1408. Published online 2020 Oct 17. doi: 10.1093/cercor/bhaa310

PMCID:: PMC7786363

Article PDF–1.5M

Select item 67582334.

Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABA_AReceptor

Neil Collinson, Frederick M. Kuenzi, Wolfgang Jarolimek, Karen A. Maubach, Rosa Cothliff, Cyrille Sur, Alison Smith, Franklin M. Otu, Owain Howell, John R. Atack, Ruth M. McKernan, Guy R. Seabrook, Gerry R. Dawson, Paul J. Whiting, Thomas W. Rosahl

J Neurosci. 2002 Jul 1; 22(13): 5572–5580. doi: 10.1523/JNEUROSCI.22-13-05572.2002

PMCID:: PMC6758233

Article PDF–470K

Select item 67299035.

Selective Enhancement of Tonic GABAergic Inhibition in Murine Hippocampal Neurons by Low Concentrations of the Volatile Anesthetic Isoflurane

Valerie B. Caraiscos, J. Glen Newell, Kong E. You-Ten, Erin M. Elliott, Thomas W. Rosahl, Keith A. Wafford, John F. MacDonald, Beverley A. Orser

J Neurosci. 2004 Sep 29; 24(39): 8454–8458. doi: 10.1523/JNEUROSCI.2063-04.2004

PMCID:: PMC6729903

Article PDF–807K

Select item 67297216.

Requirement of α₅-GABA_A Receptors for the Development of Tolerance to the Sedative Action of Diazepam in Mice

Carolien van Rijnsoever, Marcus Täuber, Mohamed Khaled Choulli, Ruth Keist, Uwe Rudolph, Hanns Mohler, Jean Marc Fritschy, Florence Crestani

J Neurosci. 2004 Jul 28; 24(30): 6785–6790. doi: 10.1523/JNEUROSCI.1067-04.2004

PMCID:: PMC6729721

Article PDF–279K

Select item 66741277.

α5GABA_A Receptors Mediate the Amnestic But Not Sedative-Hypnotic Effects of the General Anesthetic Etomidate

Victor Y. Cheng, Loren J. Martin, Erin M. Elliott, John H. Kim, Howard T. J. Mount, Franco A. Taverna, John C. Roder, John F. MacDonald, Amit Bhambri, Neil Collinson, Keith A. Wafford, Beverley A. Orser

J Neurosci. 2006 Apr 5; 26(14): 3713–3720. doi: 10.1523/JNEUROSCI.5024-05.2006

PMCID:: PMC6674127

Article PDF–633K

Select item 66327468.

α5GABA_A Receptor Activity Sets the Threshold for Long-Term Potentiation and Constrains Hippocampus-Dependent Memory

Loren J. Martin, Agnieszka A. Zurek, John F. MacDonald, John C. Roder, Michael F. Jackson, Beverley A. Orser

J Neurosci. 2010 Apr 14; 30(15): 5269–5282. doi: 10.1523/JNEUROSCI.4209-09.2010

PMCID:: PMC6632746

Article PDF–2.2M

Select item 50129619.

Partial inactivation of GABA_A receptors containing the α5 subunit affects the development of adult-born dentate gyrus granule cells

Francine Deprez, Fabia Vogt, Amalia Floriou-Servou, Carlos Lafourcade, Uwe Rudolph, Shiva K. Tyagarajan, Jean-Marc Fritschy

Eur J Neurosci. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: Eur J Neurosci. 2016 Sep; 44(5): 2258–2271. Published online 2016 Jul 19. doi: 10.1111/ejn.13329

PMCID:: PMC5012961

Article PDF–2.1M

Select item 498784710.

A Pharmacogenetic ‘Restriction-of-Function' Approach Reveals Evidence for Anxiolytic-Like Actions Mediated by α5-Containing GABA_A Receptors in Mice

Lauren M Behlke, Rachel A Foster, Jing Liu, Dietmar Benke, Rebecca S Benham, Anna J Nathanson, Benjamin K Yee, Hanns Ulrich Zeilhofer, Elif Engin, Uwe Rudolph

Neuropsychopharmacology. 2016 Sep; 41(10): 2492–2501. Prepublished online 2016 Apr 12. Published online 2016 May 11. doi: 10.1038/npp.2016.49

PMCID:: PMC4987847

Article PDF–447K

Select item 460776711.

Regulating anxiety with extrasynaptic inhibition

Paolo Botta, Lynda Demmou, Yu Kasugai, Milica Markovic, Chun Xu, Jonathan P. Fadok, Tingjia Lu, Michael M. Poe, Li Xu, James M. Cook, Uwe Rudolph, Pankaj Sah, Francesco Ferraguti, Andreas Lüthi

Nat Neurosci. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: Nat Neurosci. 2015 Oct; 18(10): 1493–1500. Published online 2015 Aug 31. doi: 10.1038/nn.4102

PMCID:: PMC4607767

Article PDF–1.1M

Select item 457150512.

Etomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABA_A Receptors on Nonpyramidal Cells

F. Clifford Rodgers, Ewa D. Zarnowska, Kurt T. Laha, Elif Engin, Anja Zeller, Ruth Keist, Uwe Rudolph, Robert A. Pearce

J Neurosci. 2015 Jul 1; 35(26): 9707–9716. doi: 10.1523/JNEUROSCI.0315-15.2015

PMCID:: PMC4571505

Article PDF–1.3M

Select item 439162413.

Memory Deficits Induced by Inflammation Are Regulated by a5-Subunit-Containing GABA_A Receptors

Dian-Shi Wang, Agnieszka A. Zurek, Irene Lecker, Jieying Yu, Armen M. Abramian, Sinziana Avramescu, Paul A. Davies, Stephen J. Moss, Wei-Yang Lu, Beverley A. Orser

Cell Rep. Author manuscript; available in PMC 2015 Apr 9.

Published in final edited form as: Cell Rep. 2012 Sep 27; 2(3): 488–496. Published online 2012 Sep 20. doi: 10.1016/j.celrep.2012.08.022

PMCID:: PMC4391624

Article PDF–1.2M

Select item 434896114.

Sustained increase in α5GABA_A receptor function impairs memory after anesthesia

Agnieszka A. Zurek, Jieying Yu, Dian-Shi Wang, Sean C. Haffey, Erica M. Bridgwater, Antonello Penna, Irene Lecker, Gang Lei, Tom Chang, Eric W.R. Salter, Beverley A. Orser

J Clin Invest. 2014 Dec 1; 124(12): 5437–5441. Published online 2014 Nov 3. doi: 10.1172/JCI76669