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Select item 67684081.

A non-circulating pool of factor XI associated with glycosaminoglycans in mice

Bassem M. Mohammed, Qiufang Cheng, Anton Matafonov, Ingrid M. Verhamme, Jonas Emsley, Keith R. McCrae, Owen J. T. McCarty, Andras Gruber, David Gailani

J Thromb Haemost. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: J Thromb Haemost. 2019 Sep; 17(9): 1449–1460. Published online 2019 Jun 17. doi: 10.1111/jth.14494

PMCID:: PMC6768408

Article PDF–850K

Select item 57878672.

Factor XI contributes to myocardial ischemia-reperfusion injury in mice

Christina U. Lorentz, Norah G. Verbout, Zhiping Cao, Lijuan Liu, Monica T. Hinds, Owen J. T. McCarty, Ivan Ivanov, Erik I. Tucker, David Gailani, András Gruber

Blood Adv. 2018 Jan 23; 2(2): 85–88. Published online 2018 Jan 10. doi: 10.1182/bloodadvances.2017004879

PMCID:: PMC5787867

Article PDF–753K

Select item 50258623.

Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection

Linda Labberton, Ellinor Kenne, Andy T. Long, Katrin F. Nickel, Antonio Di Gennaro, Rachel A. Rigg, James S. Hernandez, Lynn Butler, Coen Maas, Evi X. Stavrou, Thomas Renné

Nat Commun. 2016; 7: 12616. Published online 2016 Sep 6. doi: 10.1038/ncomms12616

PMCID:: PMC5025862

Article PDF–3.4M

Select item 48216164.

Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice

Charles E. Bane, Jr, Ivan Ivanov, Anton Matafonov, Kelli L. Boyd, Qiufang Cheng, Edward R. Sherwood, Erik I. Tucker, Stephen T. Smiley, Owen J. T. McCarty, Andras Gruber, David Gailani

PLoS One. 2016; 11(4): e0152968. Published online 2016 Apr 5. doi: 10.1371/journal.pone.0152968

PMCID:: PMC4821616

Article PDF–1.7M

Select item 38657645.

Factor XI Anion-Binding Sites are required for Productive Interactions with Polyphosphate

Yipeng Geng, Ingrid M. Verhamme, Stephanie A. Smith, Qiufang Cheng, Mao-fu Sun, John P. Sheehan, James H. Morrissey, David Gailani

J Thromb Haemost. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: J Thromb Haemost. 2013 Nov; 11(11): 10.1111/jth.12414. doi: 10.1111/jth.12414

PMCID:: PMC3865764

Article PDF–841K

Select item 27962626.

Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo

Felicitas Müller, Nicola J. Mutch, Wolfdieter A. Schenk, Stephanie A. Smith, Lucie Esterl, Henri M. Spronk, Stefan Schmidbauer, William A. Gahl, James H. Morrissey, Thomas Renné

Cell. Author manuscript; available in PMC 2010 Dec 11.

Published in final edited form as: Cell. 2009 Dec 11; 139(6): 1143–1156. doi: 10.1016/j.cell.2009.11.001

PMCID:: PMC2796262

Article PDF–2.3M

Select item 26542847.

Survival Advantage of Coagulation Factor XI-Deficient Mice during Peritoneal Sepsis

Erik I. Tucker, David Gailani, Sawan Hurst, Qiufang Cheng, Stephen R. Hanson, András Gruber

J Infect Dis. Author manuscript; available in PMC 2009 Jul 15.

Published in final edited form as: J Infect Dis. 2008 Jul 15; 198(2): 271–274. doi: 10.1086/589514

PMCID:: PMC2654284

Article PDF–408K

Select item 47858938.

Factor XI Deficiency Protects Against Atherogenesis in Apolipoprotein E/Factor XI Double Knockout Mice

Reut Shnerb Ganor, Dror Harats, Ginette Schiby, David Gailani, Hanna Levkovitz, Camila Avivi, Ilia Tamarin, Aviv Shaish, Ophira Salomon

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2016 Sep 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3): 475–481. Published online 2016 Jan 21. doi: 10.1161/ATVBAHA.115.306954

PMCID:: PMC4785893

Article PDF–2.0M

Select item 36507079.

The dimeric structure of factor XI and zymogen activation

Yipeng Geng, Ingrid M. Verhamme, Stephen B. Smith, Mao-fu Sun, Anton Matafonov, Qiufang Cheng, Stephanie A. Smith, James H. Morrissey, David Gailani

Blood. 2013 May 9; 121(19): 3962–3969. Prepublished online 2013 Mar 20. doi: 10.1182/blood-2012-12-473629

PMCID:: PMC3650707

Article

Select item 325568110.

Factor XI-Deficient Mice Display Reduced Inflammation, Coagulopathy, and Bacterial Growth during Listeriosis

Deyan Luo, Frank M. Szaba, Lawrence W. Kummer, Lawrence L. Johnson, Erik I. Tucker, Andras Gruber, David Gailani, Stephen T. Smiley

Infect Immun. 2012 Jan; 80(1): 91–99. doi: 10.1128/IAI.05568-11

PMCID:: PMC3255681

Article PDF–1.9M

Select item 640533511.

A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain

Ivan Ivanov, Anton Matafonov, Mao-fu Sun, Bassem M. Mohammed, Qiufang Cheng, S. Kent Dickeson, Suman Kundu, Ingrid M. Verhamme, Andras Gruber, Keith McCrae, David Gailani

Blood. 2019 Mar 7; 133(10): 1152–1163. Prepublished online 2018 Dec 27. doi: 10.1182/blood-2018-06-860270

PMCID:: PMC6405335

Article

Select item 377473912.

Regulation of the F11, Klkb1, Cyp4v3 Gene Cluster in Livers of Metabolically Challenged Mice

Huma Safdar, Audrey C. A. Cleuren, Ka Lei Cheung, Frank J. Gonzalez, Hans L. Vos, Yusuke Inoue, Pieter H. Reitsma, Bart J. M. van Vlijmen

PLoS One. 2013; 8(9): e74637. Published online 2013 Sep 16. doi: 10.1371/journal.pone.0074637

PMCID:: PMC3774739

Article PDF–571K

Select item 298154613.

A role for factor XIIa–mediated factor XI activation in thrombus formation in vivo

Qiufang Cheng, Erik I. Tucker, Meghann S. Pine, India Sisler, Anton Matafonov, Mao-fu Sun, Tara C. White-Adams, Stephanie A. Smith, Stephen R. Hanson, Owen J. T. McCarty, Thomas Renné, András Gruber, David Gailani

Blood. 2010 Nov 11; 116(19): 3981–3989. Prepublished online 2010 Jul 15. doi: 10.1182/blood-2010-02-270918

PMCID:: PMC2981546

Article

Select item 189533914.

The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice

Qiufang Cheng, Yong Zhao, William E. Lawson, Vasiliy V. Polosukhin, Joyce E. Johnson, Timothy S. Blackwell, David Gailani

Blood. 2005 Nov 1; 106(9): 3055–3057. Prepublished online 2005 Jun 28. doi: 10.1182/blood-2005-02-0577

PMCID:: PMC1895339

Article

Select item 478684315.

Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease

Erica M. Sparkenbaugh, Pichika Chantrathammachart, Kasemsiri Chandarajoti, Nigel Mackman, Nigel S. Key, Rafal Pawlinski

Blood. 2016 Mar 10; 127(10): 1371–1373. doi: 10.1182/blood-2015-11-681114

PMCID:: PMC4786843

Article

Select item 275677616.

Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2)

Tara C. White-Adams, Michelle A. Berny, Erik I. Tucker, Jacqueline M. Gertz, David Gailani, Rolf T. Urbanus, Philip G. de Groot, András Gruber, Owen J. T. McCarty

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2010 Oct 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2009 Oct; 29(10): 1602–1607. Published online 2009 Aug 6. doi: 10.1161/ATVBAHA.109.187393

PMCID:: PMC2756776

Article PDF–1.7M

Select item 221300017.

Defective thrombus formation in mice lacking coagulation factor XII

Thomas Renné, Miroslava Pozgajová, Sabine Grüner, Kai Schuh, Hans-Ulrich Pauer, Peter Burfeind, David Gailani, Bernhard Nieswandt

J Exp Med. 2005 Jul 18; 202(2): 271–281. doi: 10.1084/jem.20050664

PMCID:: PMC2213000

Article PDF–1.3M

Select item 211822818.

Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis

Christoph Kleinschnitz, Guido Stoll, Martin Bendszus, Kai Schuh, Hans-Ulrich Pauer, Peter Burfeind, Christoph Renné, David Gailani, Bernhard Nieswandt, Thomas Renné

J Exp Med. 2006 Mar 20; 203(3): 513–518. doi: 10.1084/jem.20052458

PMCID:: PMC2118228

Article PDF–1.8M

Select item 1025091719.

Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation

Leonid A. Parunov, Yideng Liang, Qijin Lu, Alexey M. Shibeko, Erik I. Tucker, Timothy K. Lee, Fazoil I. Ataullakhanov, Dorothy E. Scott, Mikhail V. Ovanesov

Blood Adv. 2023 Jun 13; 7(11): 2622–2631. Published online 2023 Feb 3. doi: 10.1182/bloodadvances.2022008743

PMCID:: PMC10250917

Article PDF–1.2M

Select item 456681220.

The polyphosphate–factor XII pathway drives coagulation in prostate cancer-associated thrombosis

Katrin F. Nickel, Göran Ronquist, Florian Langer, Linda Labberton, Tobias A. Fuchs, Carsten Bokemeyer, Guido Sauter, Markus Graefen, Nigel Mackman, Evi X. Stavrou, Gunnar Ronquist, Thomas Renné

Blood. 2015 Sep 10; 126(11): 1379–1389. Prepublished online 2015 Jul 7. doi: 10.1182/blood-2015-01-622811