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Select item 81520571.

IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL

Tianjiao Tang, Jing Wang, Lidan Zhang, Ying Cheng, Laura Saleh, Yanni Gu, Hongbin Zhang

BMC Cancer. 2021; 21: 603. Published online 2021 May 25. doi: 10.1186/s12885-021-08086-y

PMCID:: PMC8152057

Article PDF–5.7M

Select item 80417812.

Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status

Dinesh Kumar, Saket Awadesbhai Patel, Md. Khurshidul Hassan, Nachiketa Mohapatra, Niharika Pattanaik, Manjusha Dixit

Cell Death Dis. 2021 Apr; 12(4): 389. Published online 2021 Apr 12. doi: 10.1038/s41419-021-03673-0

PMCID:: PMC8041781

Article PDF–3.4M

Select item 56560123.

IQGAP2 is a novel interferon-alpha antiviral effector gene acting nonconventionally through the NF-κB pathway

Cynthia Brisac, Shadi Salloum, Victor Yang, Esperance AK Schaefer, Jacinta A Holmes, Stephane Chevaliez, Jian Hong, Charlie Carlton-Smith, Nadia Alatrakchi, Annie Kruger, Wenyu Lin, Raymond T Chung

J Hepatol. Author manuscript; available in PMC 2017 Nov 1.

Published in final edited form as: J Hepatol. 2016 Nov; 65(5): 972–979. Published online 2016 Jul 9. doi: 10.1016/j.jhep.2016.06.028

PMCID:: PMC5656012

Article PDF–2.0M

Select item 105064794.

Upregulation of IQGAP2 by EBV transactivator Rta and its influence on EBV life cycle

Kai-Min Lin, Li-Fang Weng, Shi-Yo Jill Chen, Sue-Jane Lin, Ching-Hwa Tsai

J Virol. 2023 Aug; 97(8): e00540-23. Published online 2023 Jul 28. doi: 10.1128/jvi.00540-23

PMCID:: PMC10506479

Article PDF–2.8M

Select item 71393525.

IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity

Liang Xu, Yuling Shao, Lin Ren, Xiansheng Liu, Yunyun Li, Jiegou Xu, Yan Ye

Int J Mol Sci. 2020 Mar; 21(6): 1968. Published online 2020 Mar 13. doi: 10.3390/ijms21061968

PMCID:: PMC7139352

Article PDF–2.4M

Select item 56581146.

Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers

Dinesh Kumar, Md. Khurshidul Hassan, Niharika Pattnaik, Nachiketa Mohapatra, Manjusha Dixit

PLoS One. 2017; 12(10): e0186977. Published online 2017 Oct 26. doi: 10.1371/journal.pone.0186977

PMCID:: PMC5658114

Article PDF–15M

Select item 44577307.

IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice

Amr M. Ghaleb, Agnieszka B. Bialkowska, Ashley J. Snider, Dmitri V. Gnatenko, Yusuf A. Hannun, Vincent W. Yang, Valentina A. Schmidt

PLoS One. 2015; 10(6): e0129314. Published online 2015 Jun 5. doi: 10.1371/journal.pone.0129314

PMCID:: PMC4457730

Article PDF–6.0M

Select item 29880698.

IQGAP1 and IQGAP2 are Reciprocally Altered in Hepatocellular Carcinoma

Colin D White, Hema Khurana, Dmitri V Gnatenko, Zhigang Li, Robert D Odze, David B Sacks, Valentina A Schmidt

BMC Gastroenterol. 2010; 10: 125. Published online 2010 Oct 26. doi: 10.1186/1471-230X-10-125

PMCID:: PMC2988069

Article PDF–955K

Select item 58461509.

Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2

E. Sila Ozdemir, Hyunbum Jang, Attila Gursoy, Ozlem Keskin, Zhigang Li, David B. Sacks, Ruth Nussinov

J Biol Chem. 2018 Mar 9; 293(10): 3685–3699. Published online 2018 Jan 22. doi: 10.1074/jbc.RA117.001596

PMCID:: PMC5846150

Article PDF–6.2M

Select item 501468510.

The Structural Basis for Cdc42-induced Dimerization of IQGAPs

Louis LeCour, Jr., Vamsi. K. Boyapati, Jing Liu, Zhigang Li, David B. Sacks, David K. Worthylake

Structure. Author manuscript; available in PMC 2017 Sep 6.

Published in final edited form as: Structure. 2016 Sep 6; 24(9): 1499–1508. Published online 2016 Aug 11. doi: 10.1016/j.str.2016.06.016

PMCID:: PMC5014685

Article PDF–1.3M

Select item 486265811.

Targeted Sequencing and Meta-Analysis of Preterm Birth

Alper Uzun, Jessica Schuster, Bethany McGonnigal, Christoph Schorl, Andrew Dewan, James Padbury

PLoS One. 2016; 11(5): e0155021. Published online 2016 May 10. doi: 10.1371/journal.pone.0155021

PMCID:: PMC4862658

Article PDF–1.7M

Select item 438861012.

The biology of IQGAP proteins: beyond the cytoskeleton

Andrew C Hedman, Jessica M Smith, David B Sacks

EMBO Rep. 2015 Apr; 16(4): 427–446. Published online 2015 Feb 26. doi: 10.15252/embr.201439834

PMCID:: PMC4388610

Article PDF–1.5M

Select item 298734413.

A genome-wide association study for age-related hearing impairment in the Saami

Lut Van Laer, Jeroen R Huyghe, Samuli Hannula, Els Van Eyken, Dietrich A Stephan, Elina Mäki-Torkko, Pekka Aikio, Erik Fransen, Alana Lysholm-Bernacchi, Martti Sorri, Matthew J Huentelman, Guy Van Camp

Eur J Hum Genet. 2010 Jun; 18(6): 685–693. Published online 2010 Jan 13. doi: 10.1038/ejhg.2009.234

PMCID:: PMC2987344

Article PDF–398K

Select item 186510314.

PTEN-mediated segregation of phosphoinositides at the apical membrane controls epithelial morphogenesis through Cdc42

Fernando Martin-Belmonte, Ama Gassama, Anirban Datta, Wei Yu, Ursula Rescher±, Volker Gerke±, Keith Mostov

Cell. Author manuscript; available in PMC 2008 Jan 26.

Published in final edited form as: Cell. 2007 Jan 26; 128(2): 383–397. doi: 10.1016/j.cell.2006.11.051

PMCID:: PMC1865103

Article PDF–2.5M

Select item 23148915.

The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases.

S Brill, S Li, C W Lyman, D M Church, J J Wasmuth, L Weissbach, A Bernards, A J Snijders

Mol Cell Biol. 1996 Sep; 16(9): 4869–4878. doi: 10.1128/mcb.16.9.4869

PMCID:: PMC231489

Summary PDF–1.0M

Select item 339108716.

IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold

Miles J. Dixon, Alexander Gray, Martijn Schenning, Mark Agacan, Wolfram Tempel, Yufeng Tong, Lyudmila Nedyalkova, Hee-Won Park, Nicholas R. Leslie, Daan M. F. van Aalten, C. Peter Downes, Ian H. Batty

J Biol Chem. 2012 Jun 29; 287(27): 22483–22496. Published online 2012 Apr 5. doi: 10.1074/jbc.M112.352773

PMCID:: PMC3391087

Article PDF–2.4M

Select item 326394317.

IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain

Erwan Atcheson, Elaine Hamilton, Sevvel Pathmanathan, Brett Greer, Pat Harriott, David J. Timson

Biosci Rep. 2011 Oct 1; 31(Pt 5): 371–379. Prepublished online 2011 Feb 8. Published online 2011 Aug 5. doi: 10.1042/BSR20100123

PMCID:: PMC3263943

Article

Select item 381232418.

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans

J L Del-Aguila, A L Beitelshees, R M Cooper-DeHoff, A B Chapman, J G Gums, K Bailey, Y Gong, S T Turner, J A Johnson, E Boerwinkle

Pharmacogenomics J. 2014 Feb; 14(1): 35–40. Published online 2013 Feb 12. doi: 10.1038/tpj.2013.3

PMCID:: PMC3812324

Article PDF–662K

Select item 846595319.

Interactome Analysis of the Nucleocapsid Protein of SARS-CoV-2 Virus

Xiaoqin Zheng, Zeyu Sun, Liang Yu, Danrong Shi, Miaojin Zhu, Hangping Yao, Lanjuan Li

Pathogens. 2021 Sep; 10(9): 1155. Published online 2021 Sep 8. doi: 10.3390/pathogens10091155

PMCID:: PMC8465953

Article PDF–1.7M

Select item 600841020.

Agrin has a pathological role in the progression of oral cancer

César Rivera, Flávia Silva Zandonadi, Celeste Sánchez-Romero, Ciro Dantas Soares, Daniela Campos Granato, Wilfredo Alejandro González-Arriagada, Adriana Franco Paes Leme

Br J Cancer. 2018 Jun 12; 118(12): 1628–1638. Published online 2018 Jun 6. doi: 10.1038/s41416-018-0135-5