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MCF-7 Cell Growth Study from US Patent US20240043442: "SELECTIVE ESTROGEN RECEPTOR DEGRADERS AND USES THEREOF"
Assay data:50 Active, 30 Activity ≤ 1 nM, 50 Activity ≤ 1 µM, 50 Tested
SummaryRelated BioAssays by Target
Antiproliferative activity against human MCF7 cells
Assay data:5 Active, 2 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Summary
Antagonist activity at ERbeta expressed in HEK293/Gal4 cells incubated for 24 hrs in presence of di-arylpropionitrile by luciferase reporter gene assay
Assay data:5 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at ERalpha expressed in HEK293/Gal4 cells incubated for 24 hrs in presence of estradiol by luciferase reporter gene assay
Assay data:19 Active, 8 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 25 Tested
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiproliferative activity against human ER-positive MCF7 cells assessed as reduction in cell viability measured after 120 hrs by crystal violet staining based assay
Assay data:16 Active, 2 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 17 Tested
Breast Cancer Cell Viability Assay from US Patent US10227334: "Estrogen receptor modulators and uses thereof"
Assay data:8 Active, 4 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Induction of estrogen receptor degradation in human MCF7 cells incubated for 4 hrs by Alexafluor -488 conjugate anti-mouse IgG staining based fluorescence method
Assay data:41 Active, 40 Activity ≤ 1 nM, 42 Activity ≤ 1 µM, 42 Tested
Antagonist activity at estrogen receptor in human T47D cells incubated for 18 hrs by ultra high sensitivity luminescence reporter gene assay
Assay data:37 Active, 30 Activity ≤ 1 nM, 38 Activity ≤ 1 µM, 42 Tested
Induction of ERalpha degradation in human T47D cells
Assay data:4 Active, 3 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst staining based immunofluorescence imaging analysis
Assay data:19 Active, 19 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 19 Tested
Antagonist activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as reduction in E2-induced ER-alpha-mediated transcriptional activity by luciferase reporter gene assay
Assay data:26 Active, 3 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 31 Tested
Inhibition of cell growth in human MCF7 cells after 4 days by wst-8-based colorimetric analysis
Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Drug concentration in C57BL/6 mouse brain at 5 mg, sc measured after 0.5 hrs by LC/MS-MS analysis
Antiproliferative activity against human MCF7:WS8 cells assessed as reduction in cell viability incubated for 5 days by Hoechst 33258 dye based assay
Assay data:23 Active, 20 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 23 Tested
Antiproliferative activity against human MCF7 cells assessed as reduction in cell proliferation measured after 5 days by Cell-titer-Glo assay
Assay data:52 Active, 4 Activity ≤ 1 nM, 62 Activity ≤ 1 µM, 63 Tested
Induction of ERalpha degradation in human MCF7 cells in phenol red free RPMI medium containing 5% charcoal-stripped FBS incubated for 4 hrs by IRDye 800CW/DRAQ5 dye based in-cell Western assay
Assay data:60 Active, 12 Activity ≤ 1 nM, 63 Activity ≤ 1 µM, 63 Tested
Downregulation of human ERalpha in human MCF-7 cells after 24 hrs by in-cell Western immunoassay method
Assay data:12 Active, 2 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
Induction of ERalpha degradation in human MCF7 cells assessed as inhibition of insulin-mediated cell proliferation after 6 days by Hoechst 33258 dye-based assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested
Induction of ERalpha degradation in human MCF7 cells after 18 to 24 hrs by Western blot analysis
Assay data:20 Active, 8 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 26 Tested
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