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Antiproliferative activity against human NCI-H1975 cells incubated for 48 hrs by celltiter-Glo assay
Assay data:20 Active, 4 Activity ≤ 1 µM, 54 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Induction of microtubule fragmentation in human NCI-H1975 cells at 30 nM incubated for 12 hrs by DAPI staining based laser confocal microscopic method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Cytotoxicity against human NCI-H1975 cells harboring katanin p60 siRNA assessed as decrease in cell viability after 72 hrs by MTT assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of colony formation in human NCI-H1975 cells after 14 days by crystal violet staining based assay
Cytotoxicity against human A549 cells expressing wild type EGFR assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human CL1-5 cells expressing wild type EGFR assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human CL1-0 cells expressing wild type EGFR assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human gefitinib-resistant PC9 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human PC9 cells harboring EGFR exon-19 deletion assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells harboring EGFR T790M mutant assessed as decrease in cell viability after 72 hrs by MTT assay
Assay data:6 Active, 2 Activity ≤ 1 µM, 10 Tested
Induction of katanin p60 subunit-mediated microtubule fragmentation in human NCI-H1975 cells assessed as alpha-tubulin level in soluble form at 300 nM after 12 hrs by gel filtration chromatography/immunoblot analysis
Induction of katanin p60 subunit-mediated microtubule fragmentation in human NCI-H1975 cells at 300 nM after 12 hrs by DAPI staining based confocal laser microscopy
Induction of apoptosis in human NCI-H1975 cells assessed as increase in late apoptotic cells at 300 nM after 24 to 48 hrs by annexin V-FITC/propidium iodide double staining based flow cytometry
SummaryCompounds, ActivePubMed Citation
Induction of katanin p60 subunit-mediated JNK signaling pathway activation assessed as increase in c-Jun phosphorylation level at S63 residues in human NCI-H1975 cells at 300 nM after 6 to 12 hrs by immunoblot analysis
Induction of katanin p60 subunit-mediated JNK signaling pathway activation assessed as increase in phosphorylation level at T183/Y185 residues in human NCI-H1975 cells at 300 nM after 6 to 12 hrs by immunoblot analysis
Induction of katanin p60 subunit-mediated JNK signaling pathway activation in human NCI-H1975 cells assessed as increase in c-Jun phosphorylation at S63 residues at 300 nM after 9 hrs by phospho-kinase antibody array method
Induction of katanin p60 subunit-mediated JNK signaling pathway activation in human NCI-H1975 cells assessed as increase in JNK phosphorylation at T183/Y185 and T221/Y223 residues at 300 nM after 9 hrs by phospho-kinase antibody array method
Cell cycle arrest in human NCI-H1975 cells assessed as accumulation at G2/M phase at 300 nM after 48 hrs by propidium iodide staining based flow cytometry
Induction of apoptosis in human NCI-H1975 cells assessed as increase in cytosolic cytochrome C level at 300 nM after 6 hrs by immunoblot analysis
Induction of apoptosis in human NCI-H1975 cells assessed as increase in Bcl-2 phosphorylation at 300 nM after 1 to 12 hrs by immunoblot analysis
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