BioAssays, Active for PubChem Compound (Select 166161683) - PubChem BioAssay - NCBI

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Items: 12

Select item 19111951.

Inhibition of hERG expressed in HEK293 cells by automated patch clamp assay

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:3 Active, 3 Tested

AID:: 1911195

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 19111392.

Binding affinity to human CLpP assessed as dissociation constant by ITC method

Source:: ChEMBL

Protein Target:: ATP-dependent Clp protease proteolytic subunit, mitochondrial

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1911139

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19111353.

Antiproliferative activity against human SW480 cells incubated for 48 hrs by CCK-8 assay

Source:: ChEMBL

Assay data:6 Active, 5 Activity ≤ 1 µM, 7 Tested

AID:: 1911135

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19111344.

Antiproliferative activity against human HCT-15 cells incubated for 48 hrs by CCK-8 assay

Source:: ChEMBL

Assay data:6 Active, 5 Activity ≤ 1 µM, 7 Tested

AID:: 1911134

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19111315.

Agonist activity at human CLpP (57 to 277 amino acids) expressed in Escherichia coli using fluorogenic peptide AC-WLA-AMC as substrate incubated for 10 mins by fluorescence based assay

Source:: ChEMBL

Protein Target:: ATP-dependent Clp protease proteolytic subunit, mitochondrial

Assay data:43 Active, 33 Activity ≤ 1 µM, 52 Tested

AID:: 1911131

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19111306.

Antiproliferative activity against human DLD-1 cells incubated for 48 hrs by CCK-8 assay

Source:: ChEMBL

Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested

AID:: 1911130

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19111297.

Antiproliferative activity against human SW-620 cells incubated for 48 hrs by CCK-8 assay

Source:: ChEMBL

Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested

AID:: 1911129

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19111288.

Antiproliferative activity against human HT-29 cells incubated for 48 hrs by CCK-8 assay

Source:: ChEMBL

Assay data:6 Active, 5 Activity ≤ 1 µM, 7 Tested

AID:: 1911128

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19111279.

Antiproliferative activity against human HCT-116 cells incubated for 48 hrs by CCK-8 assay

Source:: ChEMBL

Assay data:31 Active, 19 Activity ≤ 1 µM, 52 Tested

AID:: 1911127

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 191115310.

Inhibition of colony formation in human HCT-116 cells at 12.5 to 50 nM after 14 days by crystal violet staining based method

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1911153

Summary Compounds, Active PubMed Citation

Select item 191115111.

Antiproliferative against human HCT-116 cells assessed as inhibition of tumor cell growth at 12.5 to 50 nM after 14 days by crystal violet staining based method

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1911151

Summary Compounds, Active PubMed Citation

Select item 191113812.

Binding affinity to CLpP in human HCT-116 cells assessed as protein stabilization at 10 uM incubated for 30 mins followed by heating at 46 to 74 degree celcius for 3 mins CETSA based Western blot analysis

Source:: ChEMBL

Protein Target:: ATP-dependent Clp protease proteolytic subunit, mitochondrial

Assay data:1 Active, 2 Tested

AID:: 1911138

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (12)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (8)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (9)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (12)
BioAssays extracted from the literature

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