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Antagonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as inhibition of MDP-induced NFkappaB activation-mediated SEAP release preincubated for 3 hrs followed by MDP addition and measured after 20 hrs by spectrophotometric method
Assay data:13 Active, 9 Activity ≤ 1 µM, 46 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at NOD1 in HEK-Blue hNOD1 cells assessed as inhibition of C12-iE-DAP-induced NFkappaB activation-mediated SEAP release preincubated for 3 hrs followed by C12-iE-DAP addition and measured after 20 hrs by spectrophotometric method
Assay data:26 Active, 9 Activity ≤ 1 µM, 46 Tested
Antagonist activity at NOD1 in human THP-1 cells assessed as inhibition of C12-iE-DAP-induced IkappaBalpha degradation at 1 to 10 uM preincubated for 1 hr followed by C12-iE-DAP addition and measured after 30 mins by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at NOD1 in human THP-1 cells assessed as inhibition of C12-iE-DAP-induced increase in JNK phosphorylation at 1 to 10 uM preincubated for 1 hr followed by C12-iE-DAP addition and measured after 30 mins by Western blot analysis
Antagonist activity at NOD1 in human THP-1 cells assessed as inhibition of C12-iE-DAP-induced increase in p38 phosphorylation at 1 to 10 uM preincubated for 1 hr followed by C12-iE-DAP addition and measured after 30 mins by Western blot analysis
Antagonist activity at NOD1 in human THP-1 cells assessed as inhibition of C12-iE-DAP-induced increase in p65 phosphorylation at 1 to 10 uM preincubated for 1 hr followed by C12-iE-DAP addition and measured after 30 mins by Western blot analysis
Antagonist activity at NOD1 in human THP-1 cells assessed as inhibition of C12-iE-DAP-induced increase in IKKalpha/beta phosphorylation at 1 to 10 uM preincubated for 1 hr followed by C12-iE-DAP addition and measured after 30 mins by Western blot analysis
Antagonist activity at NOD1 in human THP-1 cells assessed as inhibition of C12-iE-DAP-induced increase in RIP2 phosphorylation at 1 to 10 uM preincubated for 1 hr followed by C12-iE-DAP addition and measured after 30 mins by Western blot analysis
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