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Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay
Assay data:9 Active, 3 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of GARFTase in Chinese Hamster MTXRII-OuaR2-4 R2 cells expressing human PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay
Assay data:7 Active, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of GARFTase in Chinese Hamster D4 cells expressing human FRbeta assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay
Inhibition of GARFTase in Chinese Hamster RT16 cells expressing human FRalpha assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
Inhibition of GARFTase in Chinese Hamster PC43-10 cells expressing human RFC assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay
Assay data:3 Active, 9 Activity ≤ 1 µM, 9 Tested
Antiproliferative activity against human IGROV1 cells expressing human FR-alpha/PCFT assessed as reduction in cell viability measured after 96 hrs by Cell-Titer Blue fluorescence analysis
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of recombinant N-terminal 6His-tagged human GARFTase assessed as formation of 5,8-dideazafolate from 10-formyl-5,8-dideazafolic acid measured at every 15 seconds over 20 min by spectrophotometric analysis
Inhibition of GARFTase in human KB cells expressing RFC/FR-alpha/PCFT assessed as decrease in incorporation of [14C(U)]-glycine into [14C]formyl GAR incubated for 1 hr followed by addition of [14C(U)]-glycine measured after 16 hrs in presence of azaserine
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Inhibition of [3H]MTX uptake at human PCFT expressed in Chinese hamster R2/PCFT4 cells at pH 5.5 measured after 5 mins by Dixon plot analysis
Assay data:8 Active, 6 Activity ≤ 1 µM, 8 Tested
Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs in presence of glycine by Cell-Titer Blue assay
Assay data:9 Active, 9 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs in presence of thymidine by Cell-Titer Blue assay
Inhibition of [3H]MTX uptake at human PCFT expressed in Chinese hamster R2/PCFT4 cells at 1 uM and pH 5.5 measured after 5 mins
Assay data:1 Active, 7 Tested
Inhibition of [3H]MTX uptake at human PCFT expressed in Chinese hamster R2/PCFT4 cells at 10 uM and pH 5.5 measured after 5 mins
Antiproliferative activity against human KB cells at 0.1 to 10000 nM after 96 hrs in presence of 130 uM glycine by Cell-Titer blue assay
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed Citation
Antiproliferative activity against human KB cells at 0.1 to 10000 nM after 96 hrs in presence of 10 uM thymidine by Cell-Titer blue assay
Antiproliferative activity against wild type human IGROV1 cells after 96 hrs by Cell-Titer Blue assay
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
Antiproliferative activity against human A2780 cells after 96 hrs by Cell-Titer Blue assay
Antiproliferative activity against human IGROV1 cells harboring non targeted control shRNA sequence after 96 hrs by Cell-Titer Blue assay
Antiproliferative activity against FRalpha knockout human IGROV1 KD4 cells after 96 hrs by Cell-Titer Blue assay
Assay data:8 Active, 12 Activity ≤ 1 µM, 12 Tested
Antiproliferative activity against FRalpha knockout human IGROV1 KD10 cells after 96 hrs by Cell-Titer Blue assay
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