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Cytotoxicity against mouse B16F10 cells assessed as decrease in cell viability treated every 24 hrs measured after 72 hrs by alamar blue assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability treated every 24 hrs measured after 72 hrs by alamar blue assay
Assay data:1 Active, 3 Tested
Inhibition of USP7 in human MCF7 cells assessed as increase in p21 expression at 25 uM after 4 hrs by Western blot analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of USP7 in human MCF7 cells assessed as increase in p53 expression after 4 to 48 hrs by Western blot analysis
Inhibition of USP7 in human MCF7 cells assessed as increase in p53 expression at 25 uM after 4 hrs by Western blot analysis
Inhibition of USP7 in human MCF7 cells assessed as decrease in Mdm2 expression at 25 uM after 4 hrs by Western blot analysis
Inhibition of USP7 in human MCF7 cells assessed as accumulation of K48-Ub protein at 50 uM after 4 hrs by Western blot analysis
Cell cycle arrest in human K562 cells assessed as increase in accumulation at sub G1-phase after 24 hrs by propidium iodide staining based flow cytometry
Assay data:1 Tested
SummaryPubMed Citation
Cell cycle arrest in human K562 cells assessed as increase in accumulation at G1-phase after 24 hrs by propidium iodide staining based flow cytometry
Inhibition of USP9x in human K562 cells assessed as decrease in Bcr-Abl expression at 50 uM measured after 4 hrs in presence of proteasome inhibitor bortezomib by Western blot analysis
Inhibition of USP9x in human K562 cells assessed as decrease in Bcr-Abl expression at 50 uM measured after 2 hrs by Western blot analysis
Assay data:4 Active, 4 Tested
Inhibition of deubiquitinase in human K562 cells assessed as accumulation of K48-linked HMW-Ub protein at 50 uM measured after 2 hrs by Western blot analysis
Inhibition of 26S proteasome in HEK293T cells expressing GFP-fused Ub G76V mutant assessed as increase in GFP fluorescence
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Substrate activity at trypsin (unknown origin) by Michaelis-Menten plot analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Substrate activity at chymotrypsin (unknown origin) by Michaelis-Menten plot analysis
Inhibition of porcine pancreatic elastase
Assay data:2 Tested
Inhibition of fig ficin at 100 uM using Z-Arg-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay
Assay data:5 Tested
Inhibition of papaya papain at 100 uM using Z-Arg-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay
Inhibition of recombinant His6-tagged USP9x catalytic domain (unknown origin) assessed as association constant using Ub-AMC as substrate by fluorescence assay
Assay data:9 Tested
Inhibition of recombinant His6-tagged USP7 catalytic domain (unknown origin) assessed as association constant using Ub-AMC as substrate by fluorescence assay
Assay data:11 Tested
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