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Induction of microtubule fragmentation in human NCI-H1975 cells at 30 nM incubated for 12 hrs by DAPI staining based laser confocal microscopic method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Toxicity in Balb/c athymic nude mouse xenografted with human NCI-H1975 assessed as change in serum creatinine level at 6 mg/kg, ip administered 5 times a week for 1 month and measured on day 28
Assay data:3 Tested
SummaryPubMed Citation
Toxicity in Balb/c athymic nude mouse xenografted with human NCI-H1975 assessed as change in serum BUN level at 6 mg/kg, ip administered 5 times a week for 1 month and measured on day 28
Toxicity in Balb/c athymic nude mouse xenografted with human NCI-H1975 assessed as change in serum AST level at 6 mg/kg, ip administered 5 times a week for 1 month and measured on day 28
Toxicity in Balb/c athymic nude mouse xenografted with human NCI-H1975 assessed as change in serum ALT level at 6 mg/kg, ip administered 5 times a week for 1 month and measured on day 28
Toxicity in Balb/c athymic nude mouse xenografted with human NCI-H1975 cells assessed as change in body weight at at 6 mg/kg, ip administered 5 times a week for 1 month and measured for 31 days
Antitumor activity against human NCI-H1975 cells xenografted in Balb/c athymic nude mouse assessed as tumor size at 6 mg/kg, ip administered 5 times a week for 1 month and measured on day 31 by vernier caliper analysis (Rvb = 801.4 +/- 64.8 mm3)
Antiproliferative activity against human NCI-H1975 cells incubated for 48 hrs by celltiter-Glo assay
Assay data:20 Active, 4 Activity ≤ 1 µM, 54 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to human katanin by MST assay
Assay data:2 Tested
Cell-based high throughput primary assay to identify activators of GPR151
Assay data:6756 Active, 646675 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Cytotoxicity against human NCI-H1975 cells harboring katanin p60 siRNA assessed as decrease in cell viability after 72 hrs by MTT assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Induction of apoptosis in human NCI-H1975 cells harboring katanin p60 siRNA assessed as increase in PARP-1 cleavage at 300 nM after 24 hrs by immunoblot analysis
Assay data:1 Tested
Induction of apoptosis in human NCI-H1975 cells harboring katanin p60 siRNA assessed as increase in caspase 3 cleavage at 300 nM after 24 hrs by immunoblot analysis
Induction of c-Jun phosphorylation at S63 residues in human NCI-H1975 cells harboring katanin p60 siRNA at 300 nM after 24 hrs by immunoblot analysis
SummaryPubMed CitationRelated BioAssays by Target
Induction of JNK phosphorylation at T183/Y185 residues in human NCI-H1975 cells harboring katanin p60 siRNA at 300 nM after 24 hrs by immunoblot analysis
Induction of microtubule fragmentation in human NCI-H1975 cells harboring katanin p60 siRNA at 300 nM after 12 hrs by DAPI staining based confocal laser microscopy
Induction of microtubule fragmentation in human NCI-H1975 cells harboring katanin p60 siRNA assessed as alpha-tubulin level in polymer form at 300 nM after 1 hr by immunoblot analysis (Rvb = 54%)
Induction of microtubule fragmentation in human NCI-H1975 cells harboring katanin p60 siRNA assessed as alpha-tubulin level in soluble form at 300 nM after 1 hr by immunoblot analysis (Rvb = 46%)
Induction of porcine brain microtubule depolymerization at 0.3 to 30 uM in presence of PIPES by turbidimetric assay
Induction of porcine brain tubulin polymerization at 0.3 to 10 uM in presence of PIPES by turbidimetric assay
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