BioAssays for PubChem Compound (Select 135565884) - PubChem BioAssay - NCBI

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Select item 19482201.

Antiproliferative activity against human REC1 cells assessed as reduction in cell viability incubated for 6 days by CellTiter-Glo luminescent cell viability assay

Source:: ChEMBL

Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested

AID:: 1948220

Select item 19482182.

Inhibition of BTK phosphorylation at Tyr 223 residue in human Ramos cell incubated for 3 hrs by HTRF-based analysis

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase BTK

Assay data:30 Active, 30 Activity ≤ 1 µM, 30 Tested

AID:: 1948218

Summary Related BioAssays by Target

Select item 19482143.

Inhibition of TEC (unknown origin) preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by TR-FRET assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Tec

Assay data:28 Active, 29 Activity ≤ 1 µM, 29 Tested

AID:: 1948214

Summary Related BioAssays by Target

Select item 19482134.

Inhibition of EGFR (unknown origin) preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by TR-FRET assay

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:25 Active, 21 Activity ≤ 1 µM, 29 Tested

AID:: 1948213

Summary Related BioAssays by Target

Select item 19482125.

Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells using Biotin-AVLESEEELYSSARQ-NH2 as substrate preincubated for 1 hrs followed by substrate addition in presence of ATP at Km concentration and measured after 1 hrs by TR-FRET assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase BTK

Assay data:38 Active, 8 Activity ≤ 1 nM, 39 Activity ≤ 1 µM, 39 Tested

AID:: 1948212

Summary Related BioAssays by Target

Select item 19137296.

Selectivity interaction (p-TEC MSD assay) EUB0000646a TEC

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Tec

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913729

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19137287.

Selectivity interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a TEC

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Tec

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913728

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19137278.

Selectivity interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a ITK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase ITK/TSK

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913727

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19137269.

Selectivity interaction ( p-PLCg1 assay) EUB0000646a ITK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase ITK/TSK

Assay data:1 Active, 1 Tested

AID:: 1913726

Summary Compounds, Active Related BioAssays by Target

Select item 191372510.

Selectivity interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a FRK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase FRK

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913725

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191372411.

Selectivity interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a LCK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lck

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913724

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191372312.

Selectivity interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a FGR

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fgr

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913723

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191372213.

Selectivity interaction (Kinase panel (Reaction Biology)) EUB0000646a PTK6

Source:: ChEMBL

Protein Target:: Protein-tyrosine kinase 6

Assay data:1 Tested

AID:: 1913722

Summary Related BioAssays by Target

Select item 191372114.

Selectivity interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a PTK6

Source:: ChEMBL

Protein Target:: Protein-tyrosine kinase 6

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913721

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191372015.

Selectivity interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a JAK3

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913720

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191371916.

Selectivity interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a ERBB2

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913719

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191371817.

Selectivity interaction (p-EGFR HTRF assay) EUB0000646a EGFR

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913718

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191371718.

Selectivity interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a EGFR

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913717

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191310519.

Affinity Biochemical interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a BMX

Source:: ChEMBL

Protein Target:: Cytoplasmic tyrosine-protein kinase BMX

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913105

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191310420.

Affinity Biochemical interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a TXK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase TXK

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913104

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

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Proteins (1)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (160)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (29)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (92)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (175)
BioAssays extracted from the literature
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