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Inhibition of human HDAC6
Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryRelated BioAssays by Target
Inhibition of HDAC6 in human MV4-11 cells assessed as fold-induction of tubulin acetylation at 0.5 uM measured by immunoblotting method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human FLAG-tagged HDAC6 expressed in HEK293T cells assessed as induction of alpha-tubulin hyperacetylation up to 500 nM after 24 hrs by Western blot method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antiarthritic activity in DBA/1J mouse collagen-induced arthritis model assessed as decrease in histological scores at 30 mg/kg, ip administered every morning for 12 to 14 days measured during compound dosing relative to vehicle-treated control
SummaryPubMed Citation
Toxicity in DBA/1J mouse collagen-induced arthritis model assessed as effect on hemoglobin concentration at 30 mg/kg, ip administered every morning for 12 to 14 days measured post last dose relative to vehicle-treated control
Toxicity in DBA/1J mouse collagen-induced arthritis model assessed as effect on white blood cell count at 30 mg/kg, ip administered every morning for 12 to 14 days measured post last dose relative to vehicle-treated control
Toxicity in DBA/1J mouse collagen-induced arthritis model assessed as effect on red blood cell count at 30 mg/kg, ip administered every morning for 12 to 14 days measured post last dose relative to vehicle-treated control
Antiarthritic activity in DBA/1J mouse collagen-induced arthritis model assessed as reduction of articular bone erosion in arthritic hind paw at 30 mg/kg, ip administered every morning for 12 to 14 days measured post last dose by microCT method relative to vehicle-treated control
SummaryCompounds, ActivePubMed Citation
Antiarthritic activity in DBA/1J mouse collagen-induced arthritis model assessed as decrease in bone erosion in joints at 30 mg/kg, ip administered every morning for 12 to 14 days
Antiarthritic activity in DBA/1J mouse collagen-induced arthritis model assessed as decrease in degradation of cartilage at 30 mg/kg, ip administered every morning for 12 to 14 days
Antiarthritic activity in DBA/1J mouse collagen-induced arthritis model assessed as decrease in cellular invasion at 30 mg/kg, ip administered every morning for 12 to 14 days
Antiarthritic activity in DBA/1J mouse collagen-induced arthritis model assessed as decrease in sign of synovial inflammation at 30 mg/kg, ip administered every morning for 12 to 14 days
Antiarthritic activity in DBA/1J mouse collagen-induced arthritis model assessed as loss of body weight at 30 mg/kg, ip administered every morning for 1 week measured during compound dosing
Antiarthritic activity in DBA/1J mouse collagen-induced arthritis model assessed as reduction in paw thickness at 30 mg/kg, ip administered every morning for 1 week measured during compound dosing
Antiarthritic activity in DBA/1J mouse collagen-induced arthritis model assessed as decrease in clinical scores at 30 mg/kg, ip administered every morning for 12 to 14 days measured during compound dosing relative to vehicle-treated control
In vivo inhibition of HDAC6 in DBA/1J mouse assessed as induction of tubulin acetylation in kidney at 0.6 mg treated for 15 days by Western blot method
In vivo inhibition of HDAC6 in DBA/1J mouse assessed as induction of tubulin acetylation in liver at 0.6 mg treated for 15 days by Western blot method
Induction of apoptosis in human PBMC at 50 to 1000 nM after 24 hrs by Annexin V/propidium iodide staining-based flow cytometric method
Cell cycle arrest in human Jurkat cells at 5 to 1000 nM after 24 hrs by propidium iodide staining-based flow cytometric method
Cell cycle arrest in human HEL cells at 5 to 1000 nM after 24 hrs by propidium iodide staining-based flow cytometric method
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