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hABHD6 Endocannabinoid related and lipase panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of ABHD6 (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human ABHD6 expressed in HEK293T cells assessed as inhibition constant using 2-AG as substrate incubated for 30 mins by fluorescence plate reader assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human ABHD6 expressed in HEK293 cells using TAMRA-FP as substrate by SDS-PAGE gel based competitive ABPP assay
Inhibition of ABHD6 in mouse brain membrane using HT-01 probe as substrate incubated for 30 mins by gel based competitive ABPP assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of ABHD6 in mouse brain membrane using TAMRA-FP as substrate at 10 uM pre-incubated for 30 mins followed by substrate addition and measured after 20 mins by coomassie staining based gel competitive ABPP assay
Assay data:2 Tested
Inhibition of human recombinant ABHD6
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of human ABHD6 expressed in HEK293 cells using 1-AG as substrate incubated for 90 mins by sensitive fluorescence glycerol assay
Inhibition of ABHD6 in mouse brain membrane using FP-biotin as substrate incubated for 1 hr by LC-MS based ABPP-MudPIT analysis
Inhibition of ABHD6 in mouse brain membrane using FP-biotin as substrate at 10 uM incubated for 1 hr by LC-MS based ABPP-MudPIT analysis
Inhibition of human recombinant ABHD6 expressed in COS-7 cells in presence of FP-rhodamine labeled probe by SDS-PAGE based gel fluorescence scanning analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of ABHD6 in mouse Primary neuron cells using 2-[3H]AG as substrate at 30 uM incubated for 30 mins by liquid scintillation analysis
Inhibition of mouse ABHD6 expressed in COS-7 cells using 2-[3H]AG as substrate incubated for 30 mins by liquid scintillation analysis
Displacement of FP-rhodamine from ABHD6 in mouse brain membrane fraction preincubated for 30 mins followed by FP-rhodhamine addition for 10 mins by Activity-Based Protein Profiling analysis
Evaluation of ABHD6 Enzyme Inhibitory Activity Assay from US Patent US20240010658: "ABHD6 ANTAGONIST"
Assay data:20 Active, 14 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of ABHD6 in mouse brain membrane at 10 uM using TAMRA-FP serine hydrolase probe as substrate preincubated for 25 mins followed by substrate addition and measured after 25 mins SDS-PAGE analysis
Assay data:3 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
In Vitro Competitive Activity-Based Protein Profiling Assay from US Patent US10781211: "Spirocycle compounds and methods of making and using same"
Assay data:195 Active, 196 Activity ≤ 1 µM, 196 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Fluorescent Assay from US Patent US10662159: "ABHD6 and dual ABHD6/MGL inhibitors and their uses"
Assay data:50 Active, 60 Activity ≤ 1 µM, 60 Tested
Serine Hydrolase Activity Assay from Article 10.1021/ja062999h: "The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases."
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human ABHD6 transfected in HEK293 cells using 2-OG as substrate preincubated for 30 mins followed by substrate addition measured after 5 mins by liquid scintillation spectroscopy
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
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