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Inhibition of NPC1 in human HeLa cells assessed as increase in cholesterol accumulation in subcellular localization at 5 uM incubated for 24 hrs by filipin-staining based immunofluorescence assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of NPC1 in human HeLa cells assessed as increase in cholesterol accumulation in subcellular localization at 1 uM incubated for 24 hrs by filipin-staining based immunofluorescence assay
Assay data:2 Active, 2 Tested
Inhibition of NPC1 in HUVEC cells assessed as accumulation of cholesterol in perinuclear structure at 0.2 uM incubated for 24 hrs by filipin staining based confocal microscopy analysis
Assay data:5 Active, 5 Tested
Binding affinity to NPC1 in human A549 cells lysates grown on SILAC media at 10 uM incubated for 1 hr by LC-MS/MS analysis relative to untreated control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of NPC1 in human fibroblasts assessed as increase in cholesterol accumulation after 24 hrs by filipin staining-based assay
Assay data:1 Active, 10 Tested
Chaperone activity at FLAG/GFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as increase in localization of protein mutant in late endosomes at 1 uM after 24 hrs by Hoechst 33342 staining based fluorescence microscopic analysis
Chaperone activity at FLAG/GFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as increase in localization of protein mutant in late endosomes at 30 uM after 24 hrs by Hoechst 33342 staining based fluorescence microscopic analysis
Assay data:28 Tested
Stabilization of FLAG/GFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as up regulation of NPC1 I1061T mutant expression after 24 hrs by Hoechst 33342 staining based fluorescence microscopic analysis
Chaperone activity at FLAG/GFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as increase in localization of protein mutant in late endosomes at 10 uM after 24 hrs by Hoechst 33342 staining based fluorescence microscopic analysis
Chaperone activity at FLAG/GFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as increase in localization of protein mutant in late endosomes after 24 hrs by Hoechst 33342 staining based fluorescence microscopic analysis
Assay data:3 Active, 1 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to NPC1 in HUVEC assessed as increase in cholesterol accumulation in late endosome/lysosome at 0.2 uM after 14 hrs by filipin staining-based confocal microscopy
Assay data:4 Active, 5 Tested
Binding affinity to NPC1 (unknown origin)
Assay data:4 Active, 4 Tested
Binding affinity to human NPC1 expressed in LE/LY membrane of CHO cells at 25 uM by immunoblotting
Inhibition of mouse NPC1 interaction to Ebola virus GP expressed in LE/LY membrane of CHO cells by immunoblotting
qHTS Assay for Rab9 Promoter Activators: Hit Validation Using Renilla Luciferase Read-Out
Assay data:4 Active, 4 Activity ≤ 1 µM, 222 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS Assay for NPC1 Promoter Activators: Initial hit validation from the primary screen
Assay data:48 Active, 26 Activity ≤ 1 µM, 222 Tested
qHTS Assay for NPC1 Promoter Activators: Summary
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS Assay for NPC1 Promoter Activators
Assay data:7586 Active, 12 Activity ≤ 1 nM, 2657 Activity ≤ 1 µM, 321376 Tested
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