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Inhibition of GST-fused human Grb2-SH2 domain expressed in Escherichia coli by plate reader analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to N-terminal His6-tagged human full length GRB2 SH2 domain (1 to 217 residues) expressed in Escherichia coli assessed as increase in protein thermal stability by measuring change in melting temperature by differential scanning fluorimetry
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of FITC-Ahx-PVPePYINQSVPKRK-NH2 from N-terminal His6-tagged human full length GRB2 (1 to 217 residues) expressed in Escherichia coli assessed as inhibition constant by fluorescence anisotropy assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Displacement of FITC-Ahx-PVPePYINQSVPKRK-NH2 from N-terminal His6-tagged human full length GRB2 (1 to 217 residues) expressed in Escherichia coli by fluorescence anisotropy assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of GST-fused Grb2-SH2 domain (unknown origin) by ELISA
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to Grb2-SH2 domain (unknown origin) by ELISA
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Competitive Binding Assay from Article 10.1021/jm990229t: "Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70."
Assay data:27 Active, 1 Activity ≤ 1 µM, 50 Tested
Binding affinity to Grb2-SH2 domain (53 to 163 residues) (unknown origin) expressed in Escherichia coli assessed as association constant by ITC analysis
Assay data:18 Tested
Binding affinity to Grb2-SH2 domain (53 to 163 residues) (unknown origin) expressed in Escherichia coli assessed as change in enthalpy by ITC analysis
Binding affinity to Grb2-SH2 domain (53 to 163 residues) (unknown origin) expressed in Escherichia coli assessed as change in entropy by ITC analysis
Binding affinity to Grb2-SH2 domain (53 to 163 residues) (unknown origin) expressed in Escherichia coli assessed as change in gibbs free energy by ITC analysis
Binding affinity to Grb2-SH2 domain (unknown origin) expressed in Escherichia coli BL21 (DE23) after 1 hr by fluorescence polarization assay
Binding affinity to human GST-tagged GRB2-SH2 domain expressed in Escherichia coli BL21(DE3) pLys after 60 to 80 secs in presence of 50 mM phosphate buffer by SPR assay
Assay data:3 Tested
Binding affinity to human GST-tagged GRB2-SH2 domain expressed in Escherichia coli BL21(DE3) pLys after 60 to 80 secs in presence of 1 mM phosphate buffer by SPR assay
Binding affinity to GST-tagged Grb2-SH2 domain (58 to 160 amino acid residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using 20 mM Tris/1 mM NaPO4 buffer by SPR analysis
Binding affinity to Grb2 SH2 domain (unknown origin)
Assay data:1 Tested
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to Grb2 SH2 domain (60 to 151) (unknown origin) expressed in Escherichia coli BL21(DE3) after overnight incubation by ELISA
Binding affinity to Grb2 SH2 domain (unknown origin) by ELISA
Binding affinity to Grb2 SH2 domain (unknown origin) by isothermal titration calorimetry
Assay data:6 Tested
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