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Binding affinity to Arf1 in human HepG2 cell lysate assessed as change in denaturation temperature at 25 uM measured after 3 mins by CETSA
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of ARF6 (unknown origin)
Assay data:31 Active, 1 Activity ≤ 1 µM, 40 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biochemical Assay1 from US Patent US10849901: "Arf6 inhibitors and methods of synthesis and use thereof"
Assay data:38 Active, 1 Activity ≤ 1 nM, 38 Activity ≤ 1 µM, 38 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Biochemical Assay from US Patent US10849901: "Arf6 inhibitors and methods of synthesis and use thereof"
Assay data:119 Active, 16 Activity ≤ 1 nM, 119 Activity ≤ 1 µM, 119 Tested
Inhibition of mouse Arf6 assessed as decrease in B-max for GTP-binding on Rac1 by mant-GTP binding kinetics real-time assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding affinity to ARF5 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Inhibition of ARNO-stimulated nucleotide exchange of Arf6
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ARNO-stimulated nucleotide exchange of Arf5
Inhibition of ARNO-stimulated nucleotide exchange of Arf1
Reduction in nucleotide exchange on Arf1 using ARNO4M
Binding affinity to ADP-ribosylation factor 1 expressed HEK293 cells by surface plasmon resonance analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ADP-ribosylation factor 6 activity in mouse NIH3T3 cells assessed as increase in endogenous ARF6-GTP level at 2.5 uM relative to control
Inhibition of ADP-ribosylation factor 6 activity in mouse NIH3T3 cells assessed as increase in endogenous ARF6-GTP level at 1 uM relative to control
Inhibition of ADP-ribosylation factor 1 activity in mouse NIH3T3 cells assessed as increase in endogenous ARF1-GTP level at 2.5 uM relative to control
Inhibition of ADP-ribosylation factor 1 activity in mouse NIH3T3 cells assessed as increase in endogenous ARF1-GTP level at 1 uM relative to control
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