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Inhibition of human somatostatin receptor type 4
Assay data:1 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryRelated BioAssays by Target
Inhibition of human somatostatin receptor type 1
Binding affinity to human somatostatin receptor type 4
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to human somatostatin receptor type 1
Assay data:1 Active, 1 Tested
Agonist activity at human SST4 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay
Assay data:8 Active, 11 Activity ≤ 1 µM, 12 Tested
Agonist activity at human SST1 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay
Assay data:7 Activity ≤ 1 µM, 7 Tested
Binding Assay from US Patent US11834435: "SSTR4 agonist salts"
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Displacement of [125I]-Tyr-SRIF 14 from SST1 receptor (unknown origin) expressed in membrane measured after 90 mins by gamma counting analysis
Assay data:28 Active, 11 Activity ≤ 1 µM, 34 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [125I]-Tyr-SRIF 14 from human SST4 receptor expressed in membrane measured after 90 mins by gamma counting analysis
Assay data:58 Active, 14 Activity ≤ 1 nM, 57 Activity ≤ 1 µM, 59 Tested
Agonist activity at recombinant human SST4 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 2.5 to 20 hrs in presence of 3-isobutyl-1-methylxanthine by TR-FRET LANCE assay
Assay data:54 Active, 12 Activity ≤ 1 nM, 52 Activity ≤ 1 µM, 54 Tested
Agonist activity at human SST4
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Agonist activity at human SST1
Assay data:2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Radioligand Binding Assay from US Patent US11136312: "3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof"
Assay data:71 Active, 6 Activity ≤ 1 nM, 70 Activity ≤ 1 µM, 71 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
SSTR1 I-125 Somatostatin Competition Binding Assay for Selectivity Versus SSTR4 from US Patent US11045457: "Piperidinyl-3-(aryloxy)propanamides and propanoates"
Assay data:59 Active, 15 Activity ≤ 1 µM, 109 Tested
SSTR4 I-125 Somatostatin Competition Binding Assay from US Patent US11045457: "Piperidinyl-3-(aryloxy)propanamides and propanoates"
Assay data:109 Active, 107 Activity ≤ 1 µM, 109 Tested
Inhibition of Forskolin Stimulated cAMP in Cells Overexpressing SSTR4 from US Patent US11045457: "Piperidinyl-3-(aryloxy)propanamides and propanoates"
Assay data:208 Active, 12 Activity ≤ 1 nM, 197 Activity ≤ 1 µM, 208 Tested
Radioligand Binding Assays from US Patent US10675268: "Somatostatin receptor subtype 4 (SSTR4) agonists"
Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested
cAMP ASSAY from US Patent US10675268: "Somatostatin receptor subtype 4 (SSTR4) agonists"
Assay data:169 Active, 32 Activity ≤ 1 nM, 167 Activity ≤ 1 µM, 169 Tested
Radioligand Binding Assays from US Patent US10577336: "Morpholine and 1,4-oxazepane amides as somatostatin receptor subtype 4 (SSTR4) agonists"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Camp Assay from US Patent US10577336: "Morpholine and 1,4-oxazepane amides as somatostatin receptor subtype 4 (SSTR4) agonists"
Assay data:87 Active, 1 Activity ≤ 1 nM, 85 Activity ≤ 1 µM, 87 Tested
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