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Safety47 Scan (DiscoverX - Eurofins)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Glutamate, NMDA, Glycine Eurofins Panlabs panel
Glutamate, NMDA, Agonism Eurofins Panlabs panel
NMDA/R Eurofins SafetyScreen44 (BI)
Binding affinity towards rat Grin1 in an in vitro assay with cellular components measured by membrane filtration
Assay data:10 Active, 4 Activity ≤ 1 µM, 1125 Tested
Antagonist activity at NMDA receptor (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of GluN1/GluN2B NMDA receptor (unknown origin) expressed in HEK293 cells
Assay data:2 Active, 1 Activity ≤ 1 µM, 5 Tested
Positive allosteric modulator activity at NMDA receptor in rat Hippocampal neurone
Assay data:1 Active, 1 Tested
Positive allosteric modulation of GluN1/GluN2B receptor (unknown origin) stably expressed in HEK293 cells assessed as glutamate/glycine induced increase in intracellular calcium level at 10 uM incubated for 30 mins followed by addition of glutamate/glycine by Ca2+ influx assay
Assay data:3 Active, 4 Tested
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) stably expressed in HEK293 cells assessed as ratio of Fmax/F0 fluorescence curve value
Assay data:2 Tested
Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) stably expressed in HEK293 cells assessed as glutamate/glycine induced increase in intracellular calcium level at 10 uM incubated for 30 mins followed by addition of glutamate/glycine by Ca2+ influx assay
Assay data:4 Active, 4 Tested
Displacement of [3H]ifenprodyl from NMDA receptor (unknown origin)
Displacement of [3H]MDL from NMDA receptor (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
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