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Safety47 Scan (DiscoverX - Eurofins)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Assay data:1 Active, 1 Tested
Nicotinic Acetylcholine Eurofins Panlabs panel
N_NEURO_A4B2 Eurofins SafetyScreen44 (BI)
Binding affinity towards human CHRNA4 in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:16 Active, 3 Activity ≤ 1 µM, 1170 Tested
Binding affinity to alpha3beta4 nAChR (unknown origin) assessed as dissociation constant
Assay data:12 Active, 9 Activity ≤ 1 µM, 12 Tested
Binding affinity to alpha4beta2 nAChR (unknown origin) assessed as dissociation constant
Assay data:12 Active, 11 Activity ≤ 1 µM, 12 Tested
Inhibition of alpha4beta4 nAChR (unknown origin) at 10 uM
Inhibition of alpha4beta2 nAChR (unknown origin) at 10 uM
Inhibition of alpha3beta4 nAChR (unknown origin) at 10 uM
Inhibition of human alpha3beta4 nAChR
Assay data:2 Active, 2 Tested
Binding to Nicotinic Receptor Subtypes from US Patent US11667638: "4-substitued cytisine analogues"
Assay data:50 Active, 3 Activity ≤ 1 nM, 50 Activity ≤ 1 µM, 50 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of rat alpha6/alpha3beta4 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and measured for 1 to 5 days in presence of Ach stimulation by voltage-clamp based electrophysiological method
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human alpha6/alpha3beta4 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and measured for 1 to 5 days in presence of Ach stimulation by voltage-clamp based electrophysiological method
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