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HTRF Assay from US Patent US11787775: "Therapeutic compounds and methods of use"
Assay data:37 Active, 35 Activity ≤ 1 µM, 45 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:46 Active, 43 Activity ≤ 1 µM, 46 Tested
Inhibition of YAP binding to human TEAD4 by fluorescence polarization assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of FAM- labeled YAP1 peptide from TEAD4 (217 to 434 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant incubated for 1.5 hrs by fluorescence polarization-based competitive binding assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of FAM- labeled YAP1 peptide from TEAD2 (217 to 447 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant incubated for 1.5 hrs by fluorescence polarization-based competitive binding assay
Binding affinity to human TEAD3 (216 to 435 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as change in melting temperature incubated for 2 hrs by measuring scattering fluorescence by Nano Differential scanning fluorometry
Binding affinity to human TEAD2 (217 to 447 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as change in melting temperature incubated for 2 hrs measuring scattering fluorescence by Nano Differential scanning fluorometry
Assay data:2 Tested
Binding affinity to human TEAD1 (209 to 426 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as change in melting temperature incubated for 2 hrs by measuring scattering fluorescence by Nano Differential scanning fluorometry
Binding affinity to human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as retention time by surface plasmon resonance assay
Binding affinity to human TEAD3 (216 to 435 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as retention time by surface plasmon resonance assay
Binding affinity to human TEAD1 (209 to 426 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as retention time by surface plasmon resonance assay
Binding affinity to human TEAD2 (217 to 447 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as retention time by surface plasmon resonance assay
Inhibition of pSF-CMV-P-FLAG tagged human TEAD3 palmitoylation transfected in HEK293 cells at 1 uM incubated for 6 hrs by Western blot analysis relative to control
Inhibition of pSF-CMV-P-FLAG tagged human TEAD1 palmitoylation transfected in HEK293 cells at 100 nM incubated for 6 hrs by Western blot analysis relative to control
Inhibition of pSF-CMV-P-FLAG tagged human TEAD4 palmitoylation transfected in HEK293 cells at 10 uM incubated for 6 hrs by Western blot analysis relative to control
Assay data:8 Tested
Inhibition of pSF-CMV-P-FLAG tagged human TEAD3 palmitoylation transfected in HEK293 cells at 10 uM incubated for 6 hrs by Western blot analysis relative to control
Inhibition of pSF-CMV-P-FLAG tagged human TEAD2 palmitoylation transfected in HEK293 cells at 10 uM incubated for 6 hrs by Western blot analysis relative to control
Inhibition of pSF-CMV-P-FLAG tagged human TEAD1 palmitoylation transfected in HEK293 cells at 10 uM incubated for 6 hrs by Western blot analysis relative to control
Binding affinity to human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as change in melting temperature incubated for 2 hr by measuring tryptophane fluorescence by Nano Differential scanning fluorometry
Binding affinity to human TEAD3 (216 to 435 residues) expressed in Escherichia coli BL21 Star (DE3) assessed as change in melting temperature incubated for 2 hrs by measuring tryptophane fluorescence by Nano Differential scanning fluorometry
Assay data:7 Tested
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