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Binding affinity to human CA7 by phenol red dye based stopped flow CO2 hydration assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 17 Tested
SummaryRelated BioAssays by Target
Binding affinity to human CA7 assessed as inhibition constant
Assay data:19 Active, 5 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 19 Tested
Inhibition of human carbonic anhydrase 7 assessed as inhibition constant by a stopped flow CO2 hydrase assay
Assay data:1 Tested
Inhibition of recombinant human carbonic anhydrase 7 assessed as inhibition constant preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay
Assay data:19 Active, 19 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human CA7 assessed as inhibition constant by stopped-flow CO2 hydration assay
Assay data:9 Active, 9 Activity ≤ 1 µM, 10 Tested
Carbonic Anhydrase Eurofins-Panlabs enzyme assay
Activation of human carbonic anhydrase 7 by stopped flow assay
Assay data:4 Active, 2 Activity ≤ 1 µM, 7 Tested
Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
CA Inhibition Assay from Article 10.3109/14756366.2013.804072: "Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Thermal Shift Assay (TSA) from Article 10.3109/14756366.2012.757223: "Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII."
Assay data:43 Active, 1 Activity ≤ 1 nM, 37 Activity ≤ 1 µM, 43 Tested
CA Inhibition Assay from Article 10.3109/14756366.2011.650692: "Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors."
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
CA Activity Assay from Article 10.3109/14756366.2011.588227: "Acetaldehyde-derived modifications on cytosolic human carbonic anhydrases."
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition Assay from Article 10.1111/j.1747-0285.2009.00857.x: "Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?"
Assay data:5 Active, 2 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition Assay from Article 10.1111/j.1747-0285.2009.00842.x: "Carbonic anhydrase inhibitors: inhibition of cytosolic carbonic anhydrase isozymes II and VII with simple aromatic sulfonamides and some azo dyes."
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
CA Inhibition Assay from Article 10.1021/jm900641r: "Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors."
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
CA Inhibition Assay from Article 10.1016/j.bmc.2008.12.023: "Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference."
CA Inhibition Assay from Article 10.1016/j.bmc.2008.06.013: "Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid."
Assay data:10 Active, 3 Activity ≤ 1 µM, 11 Tested
CA Inhibition Assay from Article 10.1016/j.bmc.2008.09.032: "Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides."
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
CA Inhibition Assay from Article 10.1016/j.bmcl.2008.03.051: "Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct."
Assay data:13 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 13 Tested
CA Inhibition Assay from Article 10.1016/j.bmcl.2008.06.105: "Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies."
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
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