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Inhibition of human wild type partial length PAK5 (Y400 to H719 residues) expressed in bacterial expression system by Kinomescan assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human wild type partial length PAK6 (N298 to C681 residues) expressed in bacterial expression system by Kinomescan assay
Inhibition of human wild type PAK7 expressed in Escherichia coli assessed as remaining activity using RRRLSFAEPG peptide substrate at 1 uM by MRC screening assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human wild type PAK6 assessed as remaining activity at 1 uM by MRC screening assay relative to control
PAK7 DiscoveRx kinase panel
SummaryRelated BioAssays by Target
PAK6 DiscoveRx kinase panel
PAK6(h) Kinase panel
PAK5(h) Kinase panel
Inhibition of PAK6 (unknown origin) at 1 uM
Inhibition of PAK5 (unknown origin) at 1 uM
Inhibition of human recombinant PAK6 assessed as reduction in substrate phosphorylation at 50 to 500 nM using ATP and Ulight-CKKSRGDYMTMQIG (IRS-1) incubated for 60 min by LANCE detection method
DAPK1 Electrophoretic Mobility Shift Assay from Article 10.1002/cbic.201402512: "Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1."
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Millipore Kinase Panel Assay from US Patent US8952027: "Inhibitors of syk and JAK protein kinases"
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Fluorescence Assay from Article 10.1021/cb300623a: "A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications."
In Vitro Activity Assay from Article 10.1016/j.chembiol.2010.01.008: "Affinity reagents that target a specific inactive form of protein kinases."
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
KinomeScan assay: inhibition of PAK7
Assay data:108 Tested
KinomeScan assay: inhibition of PAK6
PAK5(PAK7LGF1) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
PAK6(PAK6CGY1) Takeda global kinase panel
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