Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of human CCR4 at 10 uM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity against CCR4 (unknown origin) assessed as inhibition of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
Agonist activity against CCR4 (unknown origin) assessed as induction of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
FLIPR Assay from US Patent US9090596: "Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated pathologies"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Cell-Based Assay from Article 10.1111/j.1747-0285.2007.00551.x: "Bipiperidinyl carboxylic acid amides as potent, selective, and functionally active CCR4 antagonists."
Assay data:17 Active, 1 Activity ≤ 1 µM, 30 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Ca Flux assay from US Patent US10246462: "Chemokine receptor modulators and uses thereof"
Assay data:71 Active, 88 Activity ≤ 1 µM, 88 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Affinity Assay from US Patent US9580412: "Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated diseases"
Assay data:21 Active, 20 Activity ≤ 1 µM, 21 Tested
Chemokine CCR4 Eurofins-Panlabs radioligand binding assay
SummaryRelated BioAssays by Target
PRESTO-Tango GPCRome screening (CCR4)
Antagonist activity at CCR4 (unknown origin) assessed as inhibition of ligand-induced calcium flux measured upto 10 uM
Displacement of [125I]chemokine from CCR4 (unknown origin) by gamma counter method
Antagonist activity at CCR4 in human MDA-MB-231 cells assessed as inhibition of CCL12-mediated chemotaxis at 100 nM after 22 hrs by transwell assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at human Gi/G0-coupled CCR4 receptor expressed in CHO-K1 cells assessed as inhibition of CCL22-induced beta arrestin2 recruitment at 500 nM preincubated for 30 mins followed by CCL22 stimulation and measured after 90 to 180 mins by pathhunter assay
Assay data:1 Active, 1 Tested
Antagonist activity at CCR4 in human Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at CCR4 in mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% mouse serum by CellTiter-Glo assay
Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL17-mediated chemotaxis preincubated for 30 mins followed by CCL17 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay
Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay
Assay data:28 Active, 26 Activity ≤ 1 µM, 31 Tested
Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay
Assay data:22 Active, 21 Activity ≤ 1 µM, 25 Tested
Antagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay
Assay data:29 Active, 28 Activity ≤ 1 µM, 30 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on