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Binding affinity to biotinylated Bap-tagged human IL-17A assessed as dissociation constant by SPR binding assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
Inhibition of human IL-17 by whole blood assay
Binding affinity to human IL-17A assessed as thermal stability by measuring increase in unfolding temperature by differential scanning fluorimetry
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity at His tagged human IL-17A expressed in Escherichia coli BL21-(DE3) assessed as dissociation constant incubated for 30 mins by MST analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of IL-17 in human PBMC
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assay
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of IL-17A (unknown origin) measured by AlphaLISA assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of IL-17A (unknown origin) measured by FRET assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Binding affinity to IL-17A (unknown origin) measured by SPR assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of IL-17A (unknown origin) by ELISA II
Human IL-17A x IL-17RA TR-FRET assay from WIPO Patent WO2022091056: "INTERLEUKIN-17 INHIBITORS"
Assay data:222 Active, 190 Activity ≤ 1 µM, 226 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
I L-17A Secretion from US Patent US10457637: "Benzenesulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (RORγ(T))"
Assay data:38 Active, 45 Activity ≤ 1 µM, 45 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
TH17 Cytokine Inhibition ELISA from US Patent US9708268: "ROR modulators and their uses"
Assay data:9 Active, 12 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Human TH17 Cytokine Inhibition ELISA Assay from US Patent US9701663: "Sulfonamide retinoic acid receptor-related orphan receptor modulators and uses thereof"
Assay data:9 Active, 11 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA method
Binding affinity to biotinylated human IL-17A assessed as inhibition of IL-17A interaction with 1L-17RA by ELISA
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Binding affinity to biotinylated human IL-17A by SPR analysis
Binding affinity to human IL-17A compound pretreated with PBS-T for 3 hrs followed by incubation with IL-17A and measured after 60 mins by pull-down assay based SDS-PAGE analysis
Binding affinity to mouse IL-17A
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