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Inhibition of CLK2 (unknown origin) at 1 uM relative to control
Assay data:3 Tested
SummaryRelated BioAssays by Target
Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis
Assay data:46 Active, 1 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 56 Tested
Inhibition of human CLK2 measured by DSF assay
Assay data:1 Active, 1 Tested
Inhibition of CLK2 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human CLK2 administered orally
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human CLK2 by NanoBRET assay
Inhibition of human CLK2
Assay data:28 Active, 1 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 28 Tested
Inhibition of human CLK2 mediated phosphorylation of SRSF4 in hMSCs assessed by TCF/LEF reporter assay
Inhibition of human CLK2 mediated phosphorylation of SRSF5 in hMSCs assessed by TCF/LEF reporter assay
Inhibition of human CLK2 mediated phosphorylation of SRSF6 in hMSCs assessed by TCF/LEF reporter assay
Inhibition of Human CLK2 mediated phosphorylation of SRSF4 in human chondrocytes assessed by TCF/LEF reporter assay
Inhibition of Human CLK2 mediated phosphorylation of SRSF5 in human chondrocytes assessed by TCF/LEF reporter assay
Inhibition of Human CLK2 mediated phosphorylation of SRSF6 in human chondrocytes assessed by TCF/LEF reporter assay
Inhibition of human CLK2 at 1 uM
Assay data:2 Tested
Inhibition of CLK1/2/4 (unknown origin) relative to control
Assay data:1 Tested
Inhibition of ATR in human HCT-116 cells preincubated for 1 hr followed by UV radiation and measured after 1 hr by Bradford assay based immunoblotting analysis
ATR Enzyme Assay from US Patent US20240025899: "TRIHETEROCYCLIC DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF"
Assay data:11 Active, 2 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biochemical Assay for Inhibitors of CLK2 Kinase Activity Assay from US Patent US11866436: "Benzo[c][2,6]naphthyridine derivatives, compositions and therapeutic uses thereof"
Assay data:181 Active, 131 Activity ≤ 1 µM, 181 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
ATR Inhibition Assay from US Patent US20230295166: "ATR INHIBITORS AND USES THEREOF"
Assay data:45 Active, 47 Activity ≤ 1 µM, 47 Tested
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