Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
IC50 Assay from US Patent US11890356: "HDAC6 inhibitors and imaging agents"
Assay data:18 Active, 16 Activity ≤ 1 µM, 18 Tested
SummaryRelated BioAssays by Target
Inhibition of full length C-terminal His/FLAG tagged human recombinant HDAC1 (1 to 482 residues) expressed in baculovirus-infected Sf9 cells using RHK-K(Ac)-AMC as substrate incubated for 2 hrs
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human recombinant HDAC6 assessed as residual activity at 2 uM relative to control
Assay data:6 Tested
Inhibition of human recombinant HDAC6 assessed as residual activity at 20 uM relative to control
Assay data:14 Tested
Inhibition of HDAC in human HeLa nuclear extract assessed as residual activity at 20 uM relative to control
Assay data:16 Tested
Inhibition of HDAC in human HCT-116 cells assessed as increase in alpha tubulin acetylation at 1 uM incubated for 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
Inhibition of HDAC in human HCT-116 cells assessed as increase in histone H3 acetylation at 1 uM incubated for 24 hrs by Western blot analysis
Inhibition of HDAC in human HCT-116 cells assessed as increase in alpha tubulin acetylation incubated for 24 hrs by Western blot analysis
Assay data:1 Tested
Inhibition of HDAC in human HCT-116 cells assessed as increase in histone H3 acetylation incubated for 24 hrs by Western blot analysis
Inhibition of HDAC11 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of HDAC6 (unknown origin)
Inhibition of HDAC4 (unknown origin)
Inhibition of HDAC3 (unknown origin)
Inhibition of HDAC2 (unknown origin)
Inhibition of HDAC1 (unknown origin)
Inhibition of HDAC in human HeLa nuclear extract at 0.1 uM using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay
Assay data:9 Tested
Inhibition of HDAC8 (unknown origin) using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 1 hr by fluorescence assay
Assay data:1 Active, 5 Tested
Inhibition of HDAC6 (unknown origin) using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 2 hrs by fluorescence assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of HDAC2 (unknown origin) using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 1 hr by fluorescence assay
Inhibition of HDAC1 (unknown origin) using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 2 hrs by fluorescence assay
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on