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hABHD12 Endocannabinoid related and lipase panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Displacement of FP-rhodamine from ABHD12 in mouse brain membrane fraction preincubated for 30 mins followed by FP-rhodhamine addition for 10 mins by Activity-Based Protein Profiling analysis
Assay data:2 Tested
Inhibition of ABHD12 in mouse brain membrane at 10 uM using TAMRA-FP serine hydrolase probe as substrate preincubated for 25 mins followed by substrate addition and measured after 25 mins SDS-PAGE analysis
Assay data:2 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human ABHD12 transfected in HEK293 cells using 2-OG as substrate preincubated for 30 mins followed by substrate addition measured after 5 mins by liquid scintillation spectroscopy
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ABHD12 in mouse brain membrane up to 30 uM preincubated for 25 mins followed by TAMRA-FP labeling addition and measured after 5 mins by competitive ABPP based analysis
Assay data:4 Tested
Inhibition of human ABHD12 expressed in HEK293 cells using [3H]2-OG as substrate at 10 uM preincubated for 30 mins followed by substrate addition and measured after 5 mins by liquid scintillation spectroscopy
Inhibition of human ABHD12 expressed in HEK293 cells using [3H]2-OG as substrate preincubated for 30 mins followed by substrate addition and measured after 5 mins by liquid scintillation spectroscopy
Inhibition of human ABHD12 expressed in HEK293 cells using 2-OG as substrate preincubated for 30 mins followed by substrate addition and measured after 5 mins by liquid scintillation spectroscopy
Assay data:2 Active, 1 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human ABHD12 expressed in HEK293 cell homogenates at 10 uM using [ethanolamine-1-3H]AEA as substrate after 15 mins by liquid scintillation spectroscopy
Inhibition of human ABHD12 expressed in HEK293 cell homogenates pre-incubated for 30 mins in presence of [1,2,3-3H]2-OG by liquid scintillation spectroscopy
Inhibition of ABHD12 in PMA-differentiated human THP1 cells assessed as increase in CCL4 production at 1 uM treated simultaneously with IFN-gamma/LPS for 24 hrs and measured 6 to 24 hrs after stimulation
Inhibition of ABHD12 in PMA-differentiated human THP1 cells assessed as increase in CCL3 production at 1 uM treated simultaneously with IFN-gamma/LPS for 24 hrs and measured 6 to 24 hrs after stimulation
Inhibition of ABHD12 in PMA-differentiated human THP1 cells assessed as increase in IL-1beta production at 1 uM treated simultaneously with IFN-gamma/LPS for 24 hrs and measured 6 to 24 hrs after stimulation
Inhibition of ABHD12 in PMA-differentiated human THP1 cells assessed as increase in TNF-alpha production at 1 uM treated simultaneously with IFN-gamma/LPS for 24 hrs and measured 6 to 24 hrs after stimulation
Inhibition of ABHD12 in PMA-differentiated human THP1 cells assessed as increase in CCL4 production treated simultaneously with IFN-gamma/LPS for 24 hrs and measured 6 to 24 hrs after stimulation
Inhibition of ABHD12 in PMA-differentiated human THP1 cells assessed as increase in CCL3 production treated simultaneously with IFN-gamma/LPS for 24 hrs and measured 6 to 24 hrs after stimulation
Inhibition of ABHD12 in PMA-differentiated human THP1 cells assessed as increase in IL-1beta production treated simultaneously with IFN-gamma/LPS for 24 hrs and measured 6 to 24 hrs after stimulation
Inhibition of ABHD12 in PMA-differentiated human THP1 cells assessed as increase in TNF-alpha production treated simultaneously with IFN-gamma/LPS for 24 hrs and measured 6 to 24 hrs after stimulation
Time dependent inhibition of FP-Rh binding to ABHD12 (unknown origin) expressed in HEK293T cell membranes by gel-based ABPP assay
Inhibition of ABHD12 (unknown origin) expressed in HEK293T cell membranes at 10 uM using 17:1 lyso-PS as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins by LC-MS analysis
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