BioAssay by Target (List) for Gene (Select 8445) - PubChem BioAssay - NCBI

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Select item 19197791.

DYRK2 Kinase Activity Analysis and Detection Method from US Patent US20230303553: "CDK6/DYRK2 DUAL-TARGET INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF"

Source:: BindingDB

Protein Targets:: Dual specificity tyrosine-phosphorylation-regulated kinase 2; ...
Total:: 1

Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested

AID:: 1919779

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19142242.

Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000009b DYRK2

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:1 Tested

AID:: 1914224

Summary Related BioAssays by Target

Select item 19125283.

Thermal Shift Assay. Domain: start/stop: M73-R479

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:27 Tested

AID:: 1912528

Summary Related BioAssays by Target

Select item 18999734.

Inhibition of human DYRK2 at 10 uM by radiometric kinase activity assay relative to control

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:1 Tested

AID:: 1899973

Summary PubMed Citation Related BioAssays by Target

Select item 18999725.

Inhibition of human DYRK2 at 0.1 uM by radiometric kinase activity assay relative to control

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:1 Tested

AID:: 1899972

Summary PubMed Citation Related BioAssays by Target

Select item 18967776.

Binding affinity to recombinant DYRK2 (unknown origin) assessed as change in melting temperature 10 uM by differential scanning fluorimetry

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:1 Tested

AID:: 1896777

Summary PubMed Citation Related BioAssays by Target

Select item 18920727.

Inhibition of human DYRK2 expressed in Sf9 insect cells at 1 uM incubated for 60 mins in presence of [gamma33P]ATP by microplate scintillation counter method

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:1 Tested

AID:: 1892072

Summary PubMed Citation Related BioAssays by Target

Select item 18882558.

Inhibition of Dyrk2 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:2 Tested

AID:: 1888255

Summary PubMed Citation Related BioAssays by Target

Select item 18882379.

Inhibition of DYRK2 (unknown origin) at 1 uM incubated in presence of ATP by Selectscreen kinase assay relative to control

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:2 Tested

AID:: 1888237

Summary PubMed Citation Related BioAssays by Target

Select item 187188810.

Inhibition of GST-fused human recombinant DYRK2 expressed in Escherichia coli at 10 uM using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presence of ATP by scintillation counting method

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:4 Tested

AID:: 1871888

Summary PubMed Citation Related BioAssays by Target

Select item 187188711.

Inhibition of GST-fused human recombinant DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR peptide as substrate incubated for 30 mins in presence of ATP by scintillation counting method

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:52 Active, 43 Activity ≤ 1 µM, 59 Tested

AID:: 1871887

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 187153512.

Inhibition of DYRK2 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1871535

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 186113213.

Inhibition of human recombinant GST tagged full length DYRK2 expressed in Escherichia coli expression system at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:2 Tested

AID:: 1861132

Summary PubMed Citation Related BioAssays by Target

Select item 185127714.

Inhibition of DYRK2 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1851277

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 183570515.

DYRK2 DiscoveRx kinase panel

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:1 Tested

AID:: 1835705

Summary Related BioAssays by Target

Select item 183526316.

DYRK2 SGC Tm panel (DSF)

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:1 Tested

AID:: 1835263

Summary Related BioAssays by Target

Select item 183494617.

DYRK2(h) Kinase panel

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:1 Tested

AID:: 1834946

Summary Related BioAssays by Target

Select item 183475418.

DYRK2(h) Millipore kinase panel

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:1 Tested

AID:: 1834754

Summary Related BioAssays by Target

Select item 183411019.

Inhibition of DYRK2 (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:1 Tested

AID:: 1834110

Summary PubMed Citation Related BioAssays by Target

Select item 182010820.

Inhibition of DYRK2 (unknown origin) at 10 nM using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET assay relative to control

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Assay data:1 Tested

AID:: 1820108

Summary PubMed Citation Related BioAssays by Target

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Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (9)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (55)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (39)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
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Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
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Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
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BioAssays reporting BioActivity of RNAi reagents

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BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (187)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (66)
BioAssays deposited by other experimentalists

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