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Binding Assay ATR (tracer B) from US Patent US11529356: "2-(morpholin-4-yl)-1,7-naphthyridines"
Assay data:55 Active, 53 Activity ≤ 1 µM, 55 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Binding Assay ATR (tracer A) from US Patent US11529356: "2-(morpholin-4-yl)-1,7-naphthyridines"
Assay data:430 Active, 415 Activity ≤ 1 µM, 431 Tested
Inhibition of full-length recombinant human ATR/ATRIP using p53 as substrate incubated for 30 mins in presence of ATP by HTRF assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of full-length human recombinant FLAG-tagged ATR/c-Myc-tagged ATRIP using p53 as substrate incubated for 30 mins in presence of ATP by HTRF assay
Inhibition of human FLAG-tagged ATR/c-Myc-tagged ATRIP expressed in mammalian expression system using p53 as substrate incubated for 2 hrs by fluorescence based assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of full-length human recombinant FLAG-tagged ATR/c-Myc-tagged ATRIP using p53 as substrate incubated for 30 mins in presence of ATP by fluorescence based assay
Inhibition of human ATR/ATRIP assessed as residual activity at 10 uM relative to control
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Enzymatic Assay from US Patent US11434233: "Heterocyclic inhibitors of ATR kinase"
Assay data:129 Active, 10 Activity ≤ 1 nM, 128 Activity ≤ 1 µM, 129 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
ATR-Complex Inhibition Assay from US Patent US11370798: "Compounds useful as inhibitors of ATR kinase"
Assay data:16 Active, 16 Activity ≤ 1 µM, 16 Tested
Inhibition Assay from US Patent US11117900: "Compounds useful as inhibitors of ATR kinase"
ATR/ATRIP Enzymatic Assay from US Patent US10894052: "Heterocyclic inhibitors of ATR kinase"
Assay data:35 Active, 2 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 35 Tested
ATR/ATRIP Enzymatic Assay from US Patent US10800774: "Heterocyclic inhibitors of ATR kinase"
Assay data:32 Active, 32 Activity ≤ 1 µM, 32 Tested
ATR/ATRIP Enzymatic Assay from US Patent US10800769: "Heterocyclic inhibitors of ATR kinase"
Assay data:119 Active, 10 Activity ≤ 1 nM, 118 Activity ≤ 1 µM, 119 Tested
Binding Assay ATR (tracer B) from US Patent US10772893: "2-(morpholin-4-yl)-1,7-naphthyridines"
Binding Assay ATR (tracer A) from US Patent US10772893: "2-(morpholin-4-yl)-1,7-naphthyridines"
Assay data:431 Active, 417 Activity ≤ 1 µM, 432 Tested
Enzymatic Assay from US Patent US10745420: "Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase"
Assay data:94 Active, 67 Activity ≤ 1 µM, 96 Tested
ATR Activity Assay from US Patent US10729680: "5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines"
Assay data:63 Active, 63 Activity ≤ 1 µM, 63 Tested
Enzymatic Assay from US Patent US10421765: "Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase"
Assay data:97 Active, 69 Activity ≤ 1 µM, 99 Tested
Enzymatic Assay from US Patent US10392376: "Heterocyclic inhibitors of ATR kinase"
ATR/ATRIP(h) Eurofins kinase panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
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