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Inhibition of Sprague-Dawley rat brain microsome HO-2 assessed as bilirubin formation incubated for 60 mins by double-beam spectrophotometry
Assay data:4 Active, 2 Activity ≤ 1 µM, 24 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Heme Oxygenase from Article 10.1111/j.1747-0285.2009.00909.x: "Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone."
Assay data:4 Active, 1 Activity ≤ 1 µM, 57 Tested
In Vitro HO Activity Assay from Article 10.1124/jpet.106.102699: "Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs."
Assay data:5 Active, 2 Activity ≤ 1 µM, 9 Tested
In Vitro HO Activity Assay from Article 10.1016/j.bmc.2009.01.078: "Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring."
Assay data:30 Active, 8 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of HO-2 in Sprague-Dawley rat brain microsomes using NADPH as substrate incubated for 60 mins by spectrometry based assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of HO-2 in Sprague-Dawley rat brain microsomes using NADPH as substrate preincubated for 10 mins followed by substrate addition and measured after 15 mins by GC analysis
Assay data:6 Active, 9 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant truncated HO-2 (Met1 to Ala288) in rat brain microsomes expressed in Escherichia coli by spectrometry based assay
Activation of rat brain microsome HO-2 expressed in Escherichia coli BL21 (DE3) cells preincubated for 10 mins followed by NADPH addition and measured after 15 mins by gas chromatography relative to control
Assay data:6 Tested
Inhibition of Sprague-Dawley rat brain microsome HO-2 preincubated for 10 mins followed by beta-NADPH addition and measured after 15 mins by gas chromatography
Assay data:34 Active, 3 Activity ≤ 1 µM, 35 Tested
Inhibition of rat brain microsome HO-2 preincubated for 10 mins followed by beta-NADPH addition and measured after 15 mins by gas chromatography
Assay data:2 Active, 2 Tested
Inhibition of HO-2 in Sprague-Dawley albino rat brain microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins in presence of NADPH by biliverdin reductase enzyme coupled spectrophotometric assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 25 Tested
Rat Haem oxygenase 2 (Haem oxygenase)
Assay data:1 Active, 1 Tested
Inhibition of HO2 in Sprague-Dawley rat brain microsomal fraction assessed as reduction in bilirubin formation incubated for 60 mins by double beam spectrophotometry
Assay data:7 Active, 7 Activity ≤ 1 µM, 22 Tested
Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chromatography analysis
Assay data:23 Active, 36 Tested
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis
Assay data:3 Active, 22 Tested
Inhibition of heme oxygenase-2 in Sprague-Dawley rat brain microsomal fraction assessed as carbon monoxide formation by gas chromatography
Assay data:11 Active, 1 Activity ≤ 1 µM, 34 Tested
Inhibition of Sprague-Dawley rat brain microsome HO2 at 100 uM relative to control
Assay data:7 Tested
Inhibition of Sprague-Dawley rat brain microsome HO2 at 0.1 uM relative to control
Assay data:3 Tested
Inhibition of Sprague-Dawley rat brain microsome HO2
Assay data:6 Active, 16 Tested
Inhibition of rat liver HO2
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