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Inhibition of ABHD12 in mouse brain membrane at 10 uM using TAMRA-FP serine hydrolase probe as substrate preincubated for 25 mins followed by substrate addition and measured after 25 mins SDS-PAGE analysis
Assay data:2 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of ABHD12 in mouse brain membrane up to 30 uM preincubated for 25 mins followed by TAMRA-FP labeling addition and measured after 5 mins by competitive ABPP based analysis
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of JJH350 binding to ABHD12 in mouse brain membrane proteome at 10 uM after 20 mins by CuAAC based fluorescence scanning assay relative to control
Assay data:15 Tested
Inhibition of JJH350 binding to ABHD12 in mouse brain membrane proteome at 2 uM after 20 mins by CuAAC based fluorescence scanning assay relative to control
Inhibition of JJH350 binding to ABHD12 in mouse brain membrane proteome incubated for 20 mins by CuAAC fluorescence dependent gel-based competitive ABPP assay
Assay data:24 Active, 12 Activity ≤ 1 µM, 31 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of FP-Rh probe binding to ABHD12 in mouse brain membrane proteome incubated for 45 mins by CuAAC fluorescence dependent gel-based competitive ABPP assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Binding affinity to ABHD12 in mouse brain membrane proteome at 0.016 to 10 uM incubated for 45 mins by CuAAC fluorescence dependent gel-based competitive ABPP assay
Assay data:1 Active, 1 Tested
Inhibition of ABHD12 in mouse BV2 cells preincubated for 30 mins and subsequent addition of [3H]-2-OG substrate measured after 15 mins by liquid scintillation counting method
Assay data:2 Active, 17 Tested
Inhibition of ABHD12 in mouse whole brain membranes at 32.5 uM incubated for 1 hr by TAMRA-FP probe based competitive activity-based protein profiling assay
Inhibition of ABHD12 in mouse whole brain membranes at 10 uM incubated for 1 hr by TAMRA-FP probe based competitive activity-based protein profiling assay
Assay data:1 Active, 2 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
Inhibition of Abhd12 in mouse Neuro2a cells at 3 nM after 4 hrs by ABPP-SILAC assay
Assay data:3 Tested
Inhibition of TAMRA-FP-labeled ABHD12 in mouse brain membrane at 10 uM after 1 hr by fluorescent gel scanning assay
Assay data:1 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Late stage assay provider results from the extended probe development effort to identify inhibitors of LYPLA1 and LYPLA2: Fluorescence-based biochemical gel-based ABPP inhibition potency and selectivity
Assay data:11 Active, 20 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Late stage assay provider results from the probe development effort to identify selective inhibitors of LYPLA2: LCMS-based Activity-Based Protein Profiling (ABPP) SILAC selectivity analysis in vitro
Late stage assay provider results from the probe development effort to identify selective inhibitors of LYPLA1: LCMS-based Activity-Based Protein Profiling (ABPP) SILAC selectivity analysis in vitro
Late stage assay provider results from the probe development effort to identify inhibitors of diacylglycerol lipase, beta (DAGLb): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of serine hydrolases in vitro
Assay data:3 Active, 3 Tested
Late stage assay provider results from the probe development effort to identify inhibitors of diacylglycerol lipase, beta (DAGLb): LCMS-based animal-based Activity-Based Protein Profiling (ABPP) MudPIT selectivity analysis
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