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Inhibition of PKCB (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryRelated BioAssays by Target
Inhibition of PKC (unknown origin) using acetylated myelin basic protein (4 to 14 residues) as substrate incubated for [gamma-32P]-ATP incubated for 5 mins by scintillation counter analysis
Assay data:1 Tested
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation at 100 nM incubated for 15 mins by immunoblotting analysis
Assay data:1 Active, 1 Tested
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation at 0.1 to 10 uM incubated for 15 mins by immunoblotting analysis
Assay data:3 Tested
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation at 10 uM pretreated with PMA for 24 hrs followed by compound addition and measured after 15 mins by immunoblotting analysis
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation incubated for 15 mins by immunoblotting analysis
Assay data:2 Tested
Inhibition of PKC (unknown origin)
Inhibition of Protein kinase C (unknown origin)
Assay data:3 Active, 1 Activity ≤ 1 µM, 6 Tested
Inhibition of human PKC
Protein Kinase C beta 2 (PKCpII) Assay from US Patent US11780853: "Substituted N-pyrimidin-4-yl-3-aminopyrrolo[3,4-C]pyrazoles as protein kinase C inhibitors"
Assay data:93 Active, 5 Activity ≤ 1 nM, 93 Activity ≤ 1 µM, 93 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (Kinase panel (ProQinase, FlashPlate?-based radiometric assay, 10 M ATP)) EUB0000006b PRKCB
Affinity Biochemical interaction (Filter-binding assays) EUB0000154b PRKCB
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Affinity Phenotypic Cellular interaction (Antiproliferation against diverse cancer cell lines (HCT116; PC3-prostate cacinoma cell and U87MG glioblastoma cells)) EUB0000154b PRKCB
Inhibition of PKCb2 (unknown origin)
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PKCbeta2 (unknown origin) by Z'LYTE screening method relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PKCbeta1 (unknown origin) by Z'LYTE screening method relative to control
Inhibition of PKbeta (unknown origin)
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PKCbeta2 (unknown origin) by IMAP kinase assay
Inhibition of PKCbeta1 (unknown origin) by IMAP kinase assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
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