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Binding affinity to N-terminal His-TEV-tagged human BRWD1-BD2 transfected in Escherichia coli BL21 (DE3) assessed as thermal stabilization by measuring change in melting temperature at 100 uM by SYPRO orange dye based differential scanning fluorimetry analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to human WDR9 bromodomain 2 assessed as dissociation constant by BROMOscan method
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human WDR9 bromodomain 2 assessed as residual activity at 300 nM by BROMOscan method relative to control
WDR9(2) DiscoverX BROMOscan
SummaryRelated BioAssays by Target
WDR9 (BD2) DiscoverX BROMOscan
WDR9 (2) DiscoverX BROMOscan
Inhibition of human WDR9 BD2 (A1310 to E1430 residues) at 10 uM by DiscoverX assay relative to control
Thermal Shift Assay. Domain start/stop: A1310-E1430
Assay data:10 Tested
Assay data:2 Tested
Assay data:3 Tested
Inhibition of human partial length WDR9 bromodomain 2 (A1310 to E1430 residues) expressed in bacterial expression system by BROMOscan assay
Binding affinity to human partial length WDR9 bromodomain 2 (A1310 to E1430 residues) expressed in bacterial expression system by BROMOscan assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human partial length BRWD1 (A1310 to E1430 residues) expressed in Escherichia coli BL21 cells assessed as residual binding level at 1 uM measured after 1 hr by quantitative PCR based BROMOscan assay relative to control
Binding affinity to human partial length WDR9 bromodomain 2 (A1310 to E1430 residues) expressed in bacterial expression system at 1 uM by BROMOscan assay
Binding affinity to human partial length WDR9 bromodomain 2 (A1310 to E1430 residues) expressed in bacterial expression system after 1 hr by bromoscan assay
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of human partial length BRWD1 (A1310 to E1430 residues) expressed in Escherichia coli BL21 assessed as residual activity at 1 uM after 1 hr by qPCR method relative to control
Inhibition of human partial length WDR9 bromodomain 2 (A1310 to E1430 residues) expressed in bacterial expression system assessed as residual activity at 1 uM by BROMOscan assay relative to control
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