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Enzymatic Activity Assay from US Patent US20230286970: "NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS"
Assay data:417 Active, 417 Activity ≤ 1 µM, 417 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Electrophoretic Mobility Shift Assay from US Patent US11535607: "Isoindolines as HDAC inhibitors"
Assay data:1 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of HDAC (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:16 Active, 8 Activity ≤ 1 µM, 18 Tested
Inhibition of HDAC (unknown origin) by H4 Hybrid Multi-Mode Microplate Reade
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of full length human recombinant HDAC7 expressed in Sf9 baculovirus system using FAM-labeled acetylated peptide as substrate by measuring fluorescence intensity by EMSA method
Assay data:1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Potency index, ratio of SAHA IC50 to test compound IC50 for inhibition of HDAC in human HeLa cell nuclear extracts using color de Lys as substrate
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Potency index, ratio of MS-275 IC50 to test compound IC50 for inhibition of HDAC in human HeLa cell nuclear extracts using color de Lys as substrate
Inhibition of HDAC in human HeLa cell nuclear extracts using color de Lys as substrate measured after 30 mins by colorimetric assay
Assay data:31 Active, 6 Activity ≤ 1 µM, 34 Tested
Inhibition of HDAC in human HK-2 cells assessed as increase in histone H3 expression acetylation at 5 uM measured by western blot analysis
Assay data:34 Active, 34 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of HDAC7 (unknown origin) assessed as remaining enzyme activity at 1 uM using Boc-(Trifluoroacetyl) Lysine-AMC fluorogenic peptide as substrate preincubated for 10 mins followed by substrate addition for 30 mins in presence of ATP by fluoroscence based assay relative to control
Inhibition of recombinant human HDAC7 using fluorogenic substrate by fluorescence microplate reader assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of HDAC in human MDA-MB-231 cells assessed as increase in histone H3 acetylation incubated for 24 hrs by Western blot analysis
Inhibition of HDAC in human MDA-MB-231 cells incubated for 24 hrs by fluorometric assay
Inhibition of HDAC in human MDA-MB-231 cells assessed as increase in alpha tubulin acetylation incubated for 24 hrs by Western blot analysis
Inhibition of HDAC in human SNU-16 cells assessed as reduction in phosphorylated STAT3 level at 0.11 to 1 uM incubated for 36 hrs by Western blot analysis
Assay data:1 Active, 2 Tested
Inhibition of HDAC in human HCT-116 cells assessed as reduction in phosphorylated STAT3 level at 0.11 to 1 uM incubated for 36 hrs by Western blot analysis
Inhibition of HDAC in human SNU-16 cells assessed as upregulation of acetyl-histone 3 level at 1 to 100 nM incubated for 36 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
Inhibition of HDAC in human SNU-16 cells assessed as upregulation of acetyl-histone 3 level at 1.25 to 5 uM incubated for 36 hrs by Western blot analysis
Inhibition of HDAC in human HCT-116 cells assessed as upregulation of acetyl-histone 3 level at 1.25 to 5 uM incubated for 36 hrs by Western blot analysis
Assay data:2 Active, 2 Tested
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