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Inhibition of Keap1-Nrf2 interaction in mouse peritoneal macrophages assessed as upregulation of NQO1 protein expression at 10 uM by Western blot analysis
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Keap1-Nrf2 interaction in mouse peritoneal macrophages assessed as upregulation of HO-1 protein expression at 10 uM by Western blot analysis
Inhibition of Keap1-Nrf2 interaction in mouse peritoneal macrophages assessed as increase in nuclear translocation of Nrf2 by measuring decrease in cytosolic Nrf2 level at 10 uM measured after 3 to 6 hrs by Western blot analysis
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Keap1-Nrf2 interaction in mouse peritoneal macrophages assessed as increase in nuclear translocation of Nrf2 by measuring increase in nuclear Nrf2 level at 10 uM measured after 3 to 6 hrs by Western blot analysis
Inhibition of Keap1-Nrf2 protein-protein interaction in mouse RAW264.7 cells assessed as reduction in LPS-induced nitric oxide expression measured after 12 hrs by ELISA
Assay data:1 Tested
Inhibition of Keap1-Nrf2 protein-protein interaction in mouse RAW264.7 cells assessed as reduction in LPS-induced TNFalpha expression measured after 12 hrs by ELISA
Inhibition of Keap1-Nrf2 protein-protein interaction in mouse RAW264.7 cells assessed as reduction in LPS-induced IL-6 expression measured after 12 hrs by ELISA
Inhibition of Keap1-Nrf2 protein-protein interaction in mouse RAW264.7 cells assessed as reduction in LPS-induced IL1beta expression measured after 12 hrs by ELISA
Inhibition of Keap1-Nrf2 protein-protein interaction in mouse RAW264.7 cells assessed as increase in GCLM expression by Western blot analysis
Inhibition of Keap1-Nrf2 protein-protein interaction in mouse RAW264.7 cells assessed as increase in NQO1 expression by Western blot analysis
Inhibition of Keap1-Nrf2 protein-protein interaction in mouse RAW264.7 cells assessed as increase in HO-1 expression by Western blot analysis
Inhibition of Keap1-Nrf2 protein-protein interaction in mouse RAW264.7 cells assessed as increase in GCLM mRNA expression at 10 uM measured after 4 to 16 hrs by qRT-PCR analysis
Assay data:1 Active, 1 Tested
Inhibition of Keap1-Nrf2 protein-protein interaction in mouse RAW264.7 cells assessed as increase in NQO1 mRNA expression at 10 uM measured after 4 to 16 hrs by qRT-PCR analysis
Inhibition of Keap1-Nrf2 protein-protein interaction in mouse RAW264.7 cells assessed as increase in HO-1 mRNA expression at 10 uM measured after 4 to 16 hrs by qRT-PCR analysis
Inhibition of Keap1-Nrf2 protein-protein interaction in mouse RAW264.7 cells assessed as increase in GCLM mRNA expression measured after 12 hrs by qRT-PCR analysis
Inhibition of Keap1-Nrf2 protein-protein interaction in mouse RAW264.7 cells assessed as increase in NQO1 mRNA expression measured after 12 hrs by qRT-PCR analysis
Inhibition of Keap1-Nrf2 protein-protein interaction in mouse RAW264.7 cells assessed as increase in HO-1 mRNA expression measured after 12 hrs by qRT-PCR analysis
Inhibition of Keap1-Nrf2 protein-protein interaction in mouse RAW264.7 cells assessed as activation of Nrf2 nuclear translocation at 10 uM measured after 16 hrs by Western blot analysis
Inhibition of Keap1-Nrf2 protein-protein interaction in mouse RAW264.7 cells assessed as activation of Nrf2 nuclear translocation at 10 uM measured up to 8 hrs by Western blot analysis
Activation of Nrf2 in C57BL/6 mouse assessed as increase in NQO1 expression in brain at 10 to 50 mg/kg, po administered as single dose after 2 hrs
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