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Summary
In Vitro Kinase Activity Assay from US Patent US11691950: "Isoquinoline-steroid conjugates and uses thereof"
Assay data:21 Active, 18 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of NF-kappaB phosphorylation in human HL-60 cells at 10 uM measured after 2 hrs by Immunoblotting analysis
Assay data:5 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of NF-kappaB mediated pro-inflammatory effector proteins in human THP-1 cells at 2 to 10 nM incubated for 4 hrs by western blot analysis
Assay data:3 Active, 3 Tested
Inhibition of NF-kappaB activation in human HGC-27 cells assessed as downregulation of NF-kappaB phosphorylation at 10 uM for 48 hrs by DAPI staining based immunofluorescence assay
Assay data:1 Active, 1 Tested
Inhibition of NF-kappaB activation in human RKO cells assessed as downregulation of NF-kappaB phosphorylation at 10 uM for 48 hrs by DAPI staining based immunofluorescence assay
Inhibition of NF-kappaB activation in human HT-29 cells assessed as reduction in TNFalpha-stimulated NF-kappaB nuclear translocation at 10 uM for 24 hrs followed by TNF- alpha stimulation for 1 hrs by DAPI staining based immunofluorescence assay
Inhibition of NF-kappaB (unknown origin)
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of LPS induced NF-kappaB activation (unknown origin) assessed as relative luciferase activity
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
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