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In Vitro Inhibition Activity from US Patent US11077128: "Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure"
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selective Inhibition Assays of Isolated Na,K-ATPase from US Patent US10668094: "Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure"
Assay data:21 Active, 21 Activity ≤ 1 µM, 21 Tested
Na,K-ATPase Inhibition Assay from Article 10.1074/jbc.M114.557629: "Digoxin derivatives with enhanced selectivity for the a2 isoform of Na,K-ATPase: effects on intraocular pressure in rabbits."
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
ATPase (Na+/K+) CEREP ligand profiling
Assay data:1 Tested
SummaryRelated BioAssays by Target
Competitive inhibition of Sodium/potassium-transporting ATPase (unknown origin) by liquid scintillation counting method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Na+/K+-ATPase in human placental syncytiotrophoblast-microvillous membranes/basal membranes using 3-O-methylfluorescein phosphate by fluorometric method
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Na+/K+ ATPase pump in human DU145 cells assessed as increase in intracellular calcium level at 50 uM measured after 5 hrs by Fura-2/AM dye based fluorescence assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of KCl-stimulated Na+/K+-ATPase in human placental membrane vesicles measured for 60 secs by 3-O-methylfluorescein phosphate dye based fluorometric method
Assay data:1 Active, 15 Tested
Inhibition of human Na+/K+-ATPase assessed as reduction in inorganic phosphate release from ATP incubated for 15 mins followed by ATP addition measured over 15 mins in presence of Na+/K+ by colorimetric method
Assay data:28 Active, 18 Activity ≤ 1 µM, 28 Tested
Inhibition of Sodium/potassium-transporting ATPase (unknown origin) at 1 uM
Inhibition of potassium-activated sodium/potassium ATPase in human placenta using 3-O-methylfluorescein phosphate as substrate measured for 90 secs by fluorescence assay
Assay data:12 Tested
Inhibition of potassium-activated sodium/potassium ATPase in human placenta using 3-Omethylfluorescein phosphate as substrate measured for 90 secs by fluorescence assay
Assay data:7 Tested
Inhibition of Na+/K+ ATPase (unknown origin) at 30 uM
Binding affinity to sodium/potassium-transporting ATPase (unknown origin) at 10 uM
Inhibition of Na+/K+ -ATPase in human intrauterine growth restriction placental membrane using 3-O-methylfluorescein phosphate by fluorometric method in presence of Kcl
Assay data:8 Tested
Inhibition of Na(+)/K(+) ATPase in human HeLa cells at 10 uM after 24 hrs by immunoblotting
Assay data:1 Active, 6 Tested
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