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Enzyme Activity Test from US Patent US20230295130: "COMPOUND USEFUL AS CDK7 KINASE INHIBITOR AND USE THEREOF"
Assay data:164 Active, 170 Activity ≤ 1 µM, 170 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
CDK2/Cyclin E1 Full Length Mobility Shift Assay from US Patent US11718603: "CDK2 inhibitors"
Assay data:570 Active, 350 Activity ≤ 1 nM, 570 Activity ≤ 1 µM, 570 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Kinase assay (CDK7) and IC 50 determination from WIPO Patent WO2023001061: "CDK7 SELECTIVE INHIBITORS AS ANTICANCER AGENTS"
Assay data:25 Active, 25 Activity ≤ 1 µM, 25 Tested
Inhibition of CDK7/cyclin H/MAT1 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CDK7/cyclin H/MNAT1 (unknown origin) at 1 uM in presence of ATP by Z'-LYTE assay relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CDK7/Cyclin H/MAT1 (unknown origin) in leukemia cells
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of recombinant full length human CDK7/C-terminal His-tagged Cyclin H/N-terminal GST-tagged MAT1 expressed in baculovirus in Sf21 insect cells using peptide substrate incubated for 30 mins in presence of [32P]gamma-ATP by scintillation counter method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CDK7/cyclin H/MAT1 (unknown origin) in presence of ATP by time resolved-FRET assay
Assay data:3 Active, 4 Tested
Inhibition of CDK7/cyclin-H/MNAT1 (unknown origin) at 1 uM
Assay data:1 Tested
Inhibition of full length N-terminal GST fused human CDK7 (1 to 346 residues)/CyclinH (1 to 323 residues)/ MAT1 (1 to 309 residues) expressed in baculovirus expression system using FL peptide as substrate preincubated for 30 mins followed by substrate addition and further incubated for 90 mins by EZ reader method
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
Inhibition of CDK7/cyclinH/MAT1 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Protein Kinase Assay Condition B (Thiol-Free Conditions) from US Patent US11447493: "Inhibitors of cyclin-dependent kinases"
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
Protein Kinase Assay Condition A (Thiol Containing Conditions) from US Patent US11447493: "Inhibitors of cyclin-dependent kinases"
Assay data:79 Active, 64 Activity ≤ 1 µM, 95 Tested
n Vitro CDK7 (5 nM) Assay from WIPO Patent WO2022064009: "CYCLIN-DEPENDENT KINASE 7 (CDK7) NON-COVALENT INHIBITORS"
Assay data:108 Active, 109 Activity ≤ 1 µM, 109 Tested
n Vitro CDK7 (20 nM) Assay from WIPO Patent WO2022064009: "CYCLIN-DEPENDENT KINASE 7 (CDK7) NON-COVALENT INHIBITORS"
Assay data:164 Active, 155 Activity ≤ 1 µM, 172 Tested
Biochemical Assay for CDK7 from US Patent US11186576: "Pyrazolo[1,5-A][1,3,5]triazine and pyrazolo[1,5-A]pyrimidine derivatives as CDK inhibitors"
Assay data:113 Active, 130 Activity ≤ 1 µM, 130 Tested
Biochemical Assay from US Patent US11174232: "Substituted heterocyclyl derivatives as CDK inhibitors"
Assay data:51 Active, 86 Activity ≤ 1 µM, 89 Tested
Inhibition of Kinase Activity from US Patent US10870651: "Inhibitors of cyclin-dependent kinase 7 (CDK7)"
Assay data:33 Active, 40 Activity ≤ 1 µM, 40 Tested
Inhibition In Vitro Assay from US Patent US10829490: "Substituted dihydropyrazino[1 ′,2′:1,5]pyrrolo[2,3-d]pyrimidine-based antiproliferative agents"
Assay data:4 Active, 9 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition In Vitro Assay from US Patent US10654831: "Antiproliferative pyrimidine-based compounds"
Assay data:9 Active, 3 Activity ≤ 1 µM, 14 Tested
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