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K+V channel CEREP ligand profiling
Assay data:1 Tested
SummaryRelated BioAssays by Target
K+ channel (volt-dependent) CEREP ligand profiling
K+ channel (Volt-dependent) Ligand binding assay
K+ channel (Volt-dependent) CEREP screen
Inhibition of Kv3.2 (unknown origin) by voltage clamp method
SummaryPubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Negative modulation activity at human recombinant Kv3.2 expressed in CHOK1 cells assessed as effect on activation time at -70 mV holding potential incubated for 3 mins by lonWorks Quattro system based electrophysiology assay (Rvb = 7.1 ms)
Assay data:3 Active, 3 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Positive modulation activity at human recombinant Kv3.2 expressed in CHOK1 cells assessed as effect on activation time at -70 mV holding potential incubated for 3 mins by lonWorks Quattro system based electrophysiology assay (Rvb = 7.1 ms)
Assay data:5 Active, 5 Tested
Modulation activity at human recombinant Kv3.2 expressed in CHOK1 cells assessed as potentiation of whole-cell currents by measuring activation time at 3.1 uM at -70 mV holding potential incubated for 3 mins by lonWorks Quattro system based electrophysiology assay (Rvb = 7.1 ms)
Assay data:5 Tested
Modulation activity at human recombinant Kv3.2 expressed in CHOK1 cells assessed as potentiation of whole-cell currents by measuring activation time at 0.8 uM at -70 mV holding potential incubated for 3 mins by lonWorks Quattro system based electrophysiology assay (Rvb = 7.1 ms)
Modulation activity at human recombinant Kv3.2 expressed in CHOK1 cells assessed as potentiation of whole-cell currents by measuring activation time at 0.4 uM at -70 mV holding potential incubated for 3 mins by lonWorks Quattro system based electrophysiology assay (Rvb = 7.1 ms)
Modulation activity at human recombinant Kv3.2 expressed in CHOK1 cells assessed as potentiation of whole-cell currents by measuring activation time at 0.2 uM at -70 mV holding potential incubated for 3 mins by lonWorks Quattro system based electrophysiology assay (Rvb = 7.1 ms)
Assay data:2 Tested
Modulation activity at human recombinant Kv3.2 expressed in CHOK1 cells assessed as potentiation of whole-cell currents by measuring activation time at 12.5 uM at -70 mV holding potential incubated for 3 mins by lonWorks Quattro system based electrophysiology assay (Rvb = 7.1 ms)
Modulation activity at human recombinant Kv3.2 expressed in CHOK1 cells assessed as potentiation of whole-cell currents by measuring activation time at 6.25 uM at -70 mV holding potential incubated for 3 mins by lonWorks Quattro system based electrophysiology assay (Rvb = 7.1 ms)
Modulation activity at human recombinant Kv3.2 expressed in CHOK1 cells assessed as potentiation of whole-cell currents at 25 uM at -70 mV holding potential incubated for 3 mins by lonWorks Quattro system based electrophysiology assay
Assay data:1 Active, 1 Tested
Modulation activity at human recombinant Kv3.2 expressed in CHOK1 cells assessed as potentiation of whole-cell currents at 6.3 uM at -70 mV holding potential incubated for 3 mins by lonWorks Quattro system based electrophysiology assay
Binding affinity to voltage-gated potassium channel (unknown origin) at 10 uM relative to control
Human Kv3.2 (Voltage-gated potassium channels)
Binding affinity to voltage-gated potassium channel (unknown origin) at 10 uM by radioligand binding assay
Displacement of [125-I]-dendrotoxin from Kv channel (unknown origin) at 0.1 to 10 mM
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