BioAssay by Target (List) for Gene (Select 3480) - PubChem BioAssay - NCBI

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Select item 19194551.

Enzyme-linked immunosorbent assay (ELISA) from US Patent US11655239: "Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof"

Source:: BindingDB

Protein Targets:: ALK tyrosine kinase receptor; ...
Total:: 23

Assay data:32 Active, 18 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 32 Tested

AID:: 1919455

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19135072.

Selectivity interaction (Enzymatic assay) EUB0000624a IGF1R

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Tested

AID:: 1913507

Summary Related BioAssays by Target

Select item 19134213.

Selectivity interaction (Enzymatic assay) EUB0000609a IGF1R

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913421

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19134204.

Selectivity interaction (Ambit kinase binding assay panel) EUB0000609a IGF1R

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Tested

AID:: 1913420

Summary Related BioAssays by Target

Select item 19130675.

Affinity Biochemical interaction (Radiometric kinase assay (100 M ATP)) EUB0000614a IGF1R

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913067

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19128756.

Affinity On-target Cellular interaction (Immunoblot (IGF-1-dependent autophosphorylation of IGF-1R in LISN cells)) EUB0000614a IGF1R

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912875

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19126577.

Affinity Phenotypic Cellular interaction (CellTiterGlo? luciferase-based cellular ATP assay (Promega; cell proliferation in SW620 cells)) EUB0000614a IGF1R

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912657

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19087078.

Inhibition of IGF1R (unknown origin)

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:2 Tested

AID:: 1908707

Summary PubMed Citation Related BioAssays by Target

Select item 19044889.

Inhibition of IGF1R (unknown origin)

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:3 Tested

AID:: 1904488

Summary PubMed Citation Related BioAssays by Target

Select item 189829510.

Inhibition of human IGF1R assessed as residual activity at 30 uM relative to control

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Tested

AID:: 1898295

Summary PubMed Citation Related BioAssays by Target

Select item 189407511.

Inhibition of IGF1R (unknown origin)

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894075

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 188902112.

Inhibition of IGF1R (unknown origin) at 1.0 uM relative to control

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Tested

AID:: 1889021

Summary PubMed Citation Related BioAssays by Target

Select item 188440513.

Inhibition of recombinant IGF1R (unknown origin) at 10 uM by kinase selectivity assay relative to control

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Tested

AID:: 1884405

Summary PubMed Citation Related BioAssays by Target

Select item 188394614.

Inhibition of IGF1R (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Tested

AID:: 1883946

Summary PubMed Citation Related BioAssays by Target

Select item 187807215.

Inhibition of human recombinant IGF1R expressed in baculovirus expression system at 1 uM by LanthaScreen assay

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Tested

AID:: 1878072

Summary PubMed Citation Related BioAssays by Target

Select item 187159516.

Inhibition of IGF1R (unknown origin)

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1871595

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 187156817.

Inhibition of human IGF1R expressed in baculovirus expression system using poly GT peptide as substrate preincubated for 10 mins followed by substrate and ATP addition measured after 1 hr by TR-FRET assay

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1871568

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 186038718.

Inhibition of IGF1R (unknown origin) at 0.5 uM relative to control

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Tested

AID:: 1860387

Summary PubMed Citation Related BioAssays by Target

Select item 185841219.

Inhibition of human IGF-1R using KKKSPGEYVNIEFG as substrate incubated for 40 mins in the presence of [gamma33P]ATP by scintillation counting analysis

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1858412

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 185562820.

Inhibition of IGF-1R (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Insulin-like growth factor 1 receptor

Assay data:1 Tested

AID:: 1855628

Summary PubMed Citation Related BioAssays by Target

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Proteins (4)
BioAssays with protein sequences specified as targets
RNAi Target, Active (9)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (246)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (18)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (211)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (365)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
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Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
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BioAssays reporting BioActivity of chemical reagents
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BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (780)
BioAssays extracted from the literature
NIH MLP (3)
BioAssays deposited by the NIH Molecular Libraries Program
Other (94)
BioAssays deposited by other experimentalists

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