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Inhibition of human 11beta-HSD1 expressed in HEK-293 cells incubated for 10 mins
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human11beta-HSD1 in human PBMC cells
Assay data:15 Active, 2 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human 11beta-HSD1
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of 11beta-HSD1 (unknown origin)
Assay data:39 Active, 36 Activity ≤ 1 µM, 39 Tested
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of 11beta-HSD1 in human PBMC cells using 3H-cortisone as substrate assessed as conversion of cortisone to cortisol by ELISA
Assay data:13 Active, 21 Activity ≤ 1 µM, 21 Tested
Inhibition of 11beta-HSD1 (unknown origin) using 3H-cortisone as substrate by scintillation proximity assay
Assay data:44 Active, 49 Activity ≤ 1 µM, 49 Tested
HTRF Assay from US Patent US9464044: "Compound having ability to inhibit 11Beta-HSD1 enzyme or pharmaceutically acceptable salt thereof, method for producing same, and pharmaceutical composition containing same as active ingredient"
Assay data:98 Active, 8 Activity ≤ 1 nM, 98 Activity ≤ 1 µM, 98 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Homogeneous Time Resolved Fluorescence Assay from US Patent US9163012: "Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1"
Assay data:1 Active, 3 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Scintillation Proximity Assay from US Patent US9163012: "Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1"
Assay data:69 Active, 11 Activity ≤ 1 nM, 71 Activity ≤ 1 µM, 71 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Homogeneous Time-Resolved Fluorescence (HTRF) Assay from US Patent US9120769: "Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline"
Assay data:171 Active, 100 Activity ≤ 1 µM, 171 Tested
Homogenous Time-Resolved Fluorescence (HTRF) Assay from US Patent US9073906: "Sulfamide derivative having an adamantyl group and its pharmaceutically acceptable salt"
Assay data:21 Active, 5 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 23 Tested
Homogeneous Time-Resolved Fluorescence (HTRF) from US Patent US9073870: "Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use"
Assay data:181 Active, 115 Activity ≤ 1 µM, 181 Tested
Homogeneous Time-Resolved Fluorescence (HTRF) Assay from US Patent US9029360: "Pyrazolopyrimidines as metabotropic glutamate 5 receptor antagonists"
Assay data:17 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Scintillation Proximity Assay from US Patent US8927539: "Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure"
Assay data:9 Active, 10 Activity ≤ 1 µM, 10 Tested
Enzyme Inhibition Assay from US Patent US8927536: "Tetrahydrothiazepine derivative"
Assay data:14 Active, 2 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested
Homogeneous Time-Resolved Fluorescence Assay from US Patent US8765744: "Azaspirohexanones"
Assay data:126 Active, 108 Activity ≤ 1 µM, 128 Tested
Time Resolved Fluorescence Assay from US Patent US8673938: "Chemical compounds"
Assay data:23 Active, 23 Activity ≤ 1 µM, 23 Tested
Inhibition Assay from US Patent US8598163: "Derivatives of [1,3]Oxazin-2-one useful for the treatment of metabolic diseases such as lipid disorders"
Scintillation Proximity Assay from US Patent US8598163: "Derivatives of [1,3]Oxazin-2-one useful for the treatment of metabolic diseases such as lipid disorders"
Assay data:21 Active, 11 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
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