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NR2B Antagonist Activity from US Patent US11752155: "Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders"
Assay data:56 Active, 11 Activity ≤ 1 nM, 57 Activity ≤ 1 µM, 57 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Whole-Cell Patch Clamp from US Patent US11613556: "Oxysterols and methods of use thereof"
Assay data:4 Active, 36 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Effects of Test Articles on Cloned Human NR1/GuN2B Ion Channels Expressed in Mammalian Cells from US Patent US11530210: "Substituted heteroaromatic pyrazolo-pyridines and their use as GLUN2B receptor modulators"
Assay data:281 Active, 246 Activity ≤ 1 µM, 291 Tested
Binding affinity to TCP-stimulated NMDA (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to NMDA receptor (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to NMDAR (unknown origin) assessed as inhibition constant by [3H]MK-801 binding assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by whole cell patch clamp method relative to control
Assay data:16 Tested
SummaryPubMed CitationRelated BioAssays by Target
Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by whole cell patch clamp method
Assay data:16 Active, 14 Activity ≤ 1 µM, 20 Tested
Inhibition of NMDA receptor (unknown origin) at 50 uM by radioligand receptor binding assay relative to control
Assay data:1 Tested
Antagonist activity at GluN1/GluN2B NMDA receptor (unknown origin) transfected in HEK293 cells assessed as inhibition of glycine induced current response at 10 uM in presence of L-glutamate by patch-clamp method
Assay data:2 Tested
Inhibition of NMDA receptor (unknown origin)
Displacement of [3H]ifenprodil from recombinant human GluN2B NMDA receptor (unknown origin) expressed in dexamethasone-induced mouse L-M(TK-) cell after 120 mins by microbeta scintillation counting method
Assay data:11 Active, 22 Activity ≤ 1 µM, 23 Tested
Binding affinity to NMDA receptor (unknown origin) at 100 uM patch clamp assay
Assay data:10 Tested
Antagonist activity at NMDA receptor (unknown origin) assessed as NMDA-induced depolarizations
Assay data:4 Tested
Displacement of [3H]MK-801 from NMDA receptor (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 5 Tested
Displacement of [3H]NMDA from NMDA receptor (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Displacement of [3H]L-689560 from NMDA receptor (unknown origin)
Displacement of [3H]MDL from NMDA receptor (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Displacement of [3H]AMPA from NMDA receptor (unknown origin)
Assay data:4 Active, 5 Tested
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