Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
CHIT1 Activity Assay from US Patent US11638707: "Substituted amino triazoles useful as chitinase inhibitors"
Assay data:78 Active, 77 Activity ≤ 1 µM, 78 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human AMcase expressed in Pichia pastoris GS115 using MU-(GlcNAc)2 as substrate assesed as inhibition constant incubated for 25 mins by dixon plot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Human AMCase Activity Assay from US Patent US10538508: "Substituted amino triazoles useful as human chitinase inhibitors"
Assay data:58 Active, 47 Activity ≤ 1 µM, 61 Tested
Enzymatic Assay from Article 10.1016/j.chembiol.2011.02.017: "Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor."
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Human AMCase Activity Assay from US Patent US9944624: "Substituted amino triazoles useful as human chitinase inhibitors"
Human AMCase Activity Assay from US Patent US10208020: "Substituted amino triazoles useful as human chitinase inhibitors"
Assay data:58 Active, 47 Activity ≤ 1 µM, 62 Tested
Inhibition of full-length C-terminal his-tagged human AMCase expressed in CHO-K1 cells assessed as reduction in chitinolytic activity using 4-methylumbelliferyl-beta-D-N,N-diacetylchitobioside hydrate as substrate after 60 mins by fluorometric assay
Assay data:18 Active, 16 Activity ≤ 1 µM, 18 Tested
Inhibition of full length recombinant C-terminal His-tagged human acidic mammalian chitinase expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumbelliferyl-beta-D-N,N-diacetylchitobioside hydrate as substrate incubated for 60 mins under shaking condition by microplate fluorometry analysis
Assay data:24 Active, 1 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 24 Tested
Inhibition of human acidic mammalian chitinase using 4-methylumbelliferyl-beta-D-N,N',N''-diacetylchitobioside and 4-methylumbelliferyl-beta-D-N,N',N''-diacetylchitotrioside as substrate incubated for 10 mins by microplate fluorometry analysis
Inhibition of human acidic mammalian chitinase catalytic domain overexpressed in Pichia pastoris using 4MU-(GlcNAc)2 as substrate after 30 mins by fluorescence based microplate reader analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human acidic mammalian chitinase catalytic domain overexpressed in Pichia pastoris at 10 uM using 4MU-(GlcNAc)2 as substrate after 30 mins by fluorescence based microplate reader analysis
Assay data:10 Active, 23 Tested
Inhibition of full-length C-terminal his-tagged human acidic mammalian chitinase expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumbelliferyl-beta-D-N,N-diacetylchitobioside hydrate as substrate after 60 mins by fluorometric assay
Assay data:27 Active, 24 Activity ≤ 1 µM, 27 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-beta-D-N,N'-diacetylchitobioside hydrate as substrate after 60 mins by Lineweaver-Burk plot analysis
Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-beta-D-N,N'-diacetylchitobioside hydrate as substrate after 60 mins by fluorescence assay
Assay data:17 Active, 12 Activity ≤ 1 µM, 27 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on