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Effect on rat Nav1.2 expressed in Xenopus laevis oocytes at 10 uM at holding potential of -90 mV by patch clamp electrophysiology
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Modulator activity at rat Nav1.2 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-electrode voltage clamp assay
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Na+ channel (site 2) Eurofins-Cerep binding assay
Assay data:2 Tested
SummaryRelated BioAssays by Target
Na+ channel (site 2) (rat) CEREP ligand profiling
Displacement of [3H]saxitoxin from NaV in rat brain membranes
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of rat brain Nav1.2 expressed in HEK293 cells by whole cell voltage clamp method
Rat Nav1.2 (Voltage-gated sodium channels)
Assay data:14 Active, 14 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of rat NaV1.2
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of NaV channel in rat DRG neurons under holding potential at -60 mV by patch clamp method
Assay data:12 Active, 17 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of rat NaV1.2 channel
Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysis
Assay data:18 Active, 18 Activity ≤ 1 µM, 21 Tested
Inhibition of rat Nav1.2 expressed in CHL1610 cells at -67 to -107 mV after 2 to 3 mins by whole-cell patch-clamp assay
Assay data:4 Tested
Inhibition of rat Nav1.2 expressed in CHL1610 cells at -107 mV after 2 to 3 mins by whole-cell patch-clamp assay
Inhibition of rat Nav1.2 expressed in CHL1610 cells at -67 mV after 2 to 3 mins by whole-cell patch-clamp assay
Activity at rat Nav1.2 expressed in CHL1610 cells up to 300 uM at -67 to -107 mV after 2 to 3 mins by whole-cell patch-clamp assay
Inhibition of rat brain voltage-gated sodium channel subunit alpha Nav1.2-mediated current expressed in CHO cells
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