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Inhibition of human ALDH3A1 using propionaldehyde as substrate in presence of NAD+ by UV-visible spectrophometric analysis relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of N-terminal-His6 tagged recombinant human ALDH3A1 using 4-NBA as substrate in absence of NADP+ by fluorimetric analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Substrate activity at N-terminal-His6 tagged recombinant human ALDH3A1 assessed as Kcat in presence of NADPH by fluorometric assay
Assay data:2 Tested
Substrate activity at N-terminal-His6 tagged recombinant human ALDH3A1 assessed as Ksi in presence of NADPH by fluorometric assay
Substrate activity at N-terminal-His6 tagged recombinant human ALDH3A1 assessed as Km in presence of NADPH by fluorometric assay
Assay data:1 Active, 2 Tested
Competitive inhibition of N-terminal-His6 tagged recombinant human ALDH3A1 using 4-NBA and NADP+ as substrate by Michaelis-Menten based analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Substrate activity at N-terminal-His6 tagged recombinant human ALDH3A1 at 10 uM in presence of NADPH by fluorimetric analysis relative to 4-NBA
Inhibition of N-terminal-His6 tagged recombinant human ALDH3A1 assessed as remaining enzyme activity by measuring fluorescence of NADPH using 4-NBA and NADP+ as substrate at 10 uM by fluorimetric analysis relative to control
Assay data:6 Tested
Inhibition of N-terminal-His6 tagged recombinant human ALDH3A1 assessed as reduction in NADPH production using 4-NBA and NADP+ as substrate by fluorimetric analysis
Assay data:4 Active, 6 Tested
Inhibiton Assay from US Patent US9320722: "Regulators of aldehyde dehydrogenase ALDH3A1 and related therapeutic methods"
Assay data:25 Active, 9 Activity ≤ 1 µM, 55 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
IC50 Determination from Article 10.1002/cbic.201300625: "Development of Selective Inhibitors for Human Aldehyde Dehydrogenase 3A1 (ALDH3A1) for the Enhancement of Cyclophosphamide Cytotoxicity."
Assay data:2 Active, 16 Tested
Inhibition of human ALDH3A1 assessed as NADH formation using propionaldehyde as substrate by spectrophotometry
Assay data:7 Active, 7 Tested
Inhibition of ALDH3A1 (unknown origin) assessed as NADH formation using 4-nitrobenzaldehyde as substrate
Assay data:22 Active, 12 Activity ≤ 1 µM, 24 Tested
Inhibition of recombinant C-terminal His6-tagged human ALDH3A1 (Met1 to His453 residues) expressed in mammalian expression system at 10 uM using benzaldehyde as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric method relative to control
Assay data:4 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of full length recombinant human ALDH3A1 expressed in Escherichia coli BL21(DE3) assessed as reduction in dehydrogenase activity by measuring NAD(P)H level preincubated for 2 mins followed by addition of benzaldehyde as substrate in presence of NADP+ by spectrophotometric method relative to control
Inhibition of full length recombinant human ALDH3A1 expressed in Escherichia coli BL21(DE3) assessed as remaining dehydrogenase activity by measuring NAD(P)H level at 10 uM preincubated for 2 mins followed by addition of propionaldehyde as substrate in presence of NAD+ by spectrophotometric method
Assay data:37 Tested
Inhibition of full length recombinant human ALDH3A1 expressed in Escherichia coli BL21(DE3) assessed as reduction in dehydrogenase activity by measuring NAD(P)H level preincubated for 2 mins followed by addition of benzaldehyde as substrate in presence of NADP+ by spectrophotometric method
Assay data:1 Active, 15 Tested
Inhibition of human ALDH3A1 at 20 uM
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
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