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Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysis
Assay data:17 Active, 17 Activity ≤ 1 µM, 23 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Antagonist activity at mouse MCHR1 assessed inhibition of MCH-mediated intracellular Ca2+ calcium mobilization
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of mouse MCH1R receptor
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to MCH1R in wild type mouse coronal slice expressed in CHO cells at 500 pM by radioactivity study
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of [35S] 4-(1-(3,4-difluorophenyl)-2-(ethyl(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)amino)-2-oxoethyl)-3-oxopiperazine-1-sulfonic acid from mouse MCH1R
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Ex vivo displacement of [125I]S36057 binding from mouse brain MCHR1 at 30 mg/kg, po after 24 hrs
Assay data:20 Tested
SummaryPubMed CitationRelated BioAssays by Target
Ex vivo displacement of [125I]S36057 binding from mouse brain MCHR1 at 30 mg/kg, po after 6 hrs
Assay data:27 Tested
Activity at mouse MCHR1 expressed in CHOK1-Gqi cells assessed as inhibition of MCH-induced calcium ion release by FLIPR assay
Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPA
Assay data:8 Active, 17 Activity ≤ 1 µM, 18 Tested
Inhibition of MCH-ADO binding to mouse brain at 30 mg/kg, po after 24 hrs
Assay data:6 Tested
Inhibition of MCH-ADO binding to mouse brain at 30 mg/kg, po after 6 hrs
Receptor occupancy ex vivo by displacement of [125I]S36057 binding from MCHR1 in C57BL/6N mouse brain after 24 hrs at 10 mg/kg, po
Assay data:1 Tested
Receptor occupancy ex vivo by displacement of [125I]S36057 binding from MCHR1 in C57BL/6N mouse brain after 24 hrs at 30 mg/kg, po
Assay data:19 Tested
Receptor occupancy ex vivo by displacement of [125I]S36057 binding from MCHR1 in C57BL/6N mouse brain after 6 hrs at 30 mg/kg, po
Assay data:31 Tested
Inhibitory concentration required for functional antagonism of MCH mediated Ca+2 release competing human IMR32 cells receptor in a FLIPRTM based assay
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Percent inhibition of MCH binding to MCH R1 in mouse brain slices after 6 hr
Ex vivo inhibition of MCH-ADO binding to Melanin concentrating hormone receptor 1 in mice (n=3) 24 hr r after 30 mg/kg peroral dose
Assay data:3 Tested
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