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Effect of Compound I on CSF1R Kinase Activity from US Patent US20230382871: "CSF1R KINASE INHIBITOR AND USE THEREOF"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Enzymatic Inhibitory Activity from US Patent US20230357241: "1H-PYRROLO[2,3-C]PYRIDINE COMPOUNDS AND APPLICATION THEREOF"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
CSF1R Kinase Assay from US Patent US11679110: "Methods of treating disorders using CSF1R inhibitors"
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Kinase Activity Assay from US Patent US11591328: "Highly active CSF1R inhibitor compound"
Assay data:26 Active, 2 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 26 Tested
Phospho cFMS Activity from US Patent US11530216: "Deuterated colony stimulating factor-1 receptor (CSF-1R) inhibitors"
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Selectivity interaction (Kinase panel (literature or Upstate/Millipore)) EUB0000665a CSF1R
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000147b CSF1R
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Radioactive biochemical assays (Millipore and Galapagos N.V.)) EUB0000626a CSF1R
Selectivity interaction (Ambit kinome screening platform (Ambit phage-based competition binding assay)) EUB0000624a CSF1R
Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000598a CSF1R
Affinity Biochemical interaction (Enzymatic inhibition assay (100 M ATP)) EUB0000697a CSF1R
Affinity Phenotypic Cellular interaction (Cell growth inhibition of human monocytes after stimulation with CSF-1 or GMCSF) EUB0000598a CSF1R
Affinity Phenotypic Cellular interaction (THP-1 CSF1R phosphor-Tyr assay (CSF1R autophosphorylation in human acute monocytic leukemia cell line THP-1)) EUB0000697a CSF1R
Inhibition of CSF1R (unknown origin) at 1 uM in presence of ATP by Z'-LYTE assay relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CSF1R (unknown origin) at upto 10 uM by Z'-LYTE assay
Binding affinity to wild-type human partial length CSF1R (I564 to S939 residues) expressed in bacterial expression system by Kinomescan assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CSF1R (unknown origin)
Inhibition of CSF1R (unknown origin) relative to control
Assay data:3 Tested
Binding affinity to CSF1R (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
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