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Adenosine Receptor Time-Resolved Fluorescence Resonance Energy Transfer (TRFRET) Binding Assay from US Patent US20230293517: "ANTAGONIST COMPOUNDS"
Assay data:258 Active, 137 Activity ≤ 1 nM, 258 Activity ≤ 1 µM, 258 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
ADORA2B Receptor Binding Assay from US Patent US11718622: "Heterocyclic adenosine receptor antagonists"
Assay data:173 Active, 217 Activity ≤ 1 µM, 217 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Radioligand Binding Assay from US Patent US11642336: "5-HT2A agonists for use in treatment of depression"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding Affinities to Different Adenosine Receptors from US Patent US11629147: "Triazolo-pyrimidine compounds and uses thereof"
Assay data:21 Active, 5 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
Binding Affinities to Different Adenosine Receptors from US Patent US11571420: "Pyrazine compounds and uses thereof"
Assay data:37 Active, 2 Activity ≤ 1 nM, 37 Activity ≤ 1 µM, 38 Tested
Selectivity interaction (Enzyme panel (ion channels, GPCRs, other targets)) EUB0000196bCl ADORA2B
Assay data:1 Active, 1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (GloSensor assay) EUB0000234b ADORA2B
Assay data:1 Tested
Selectivity interaction (Eurofins Panlabs Discovery Services Panel (enzymes and receptors)) EUB0000234b ADORA2B
Selectivity interaction (CEREP Wide Ligand screening panel (ion channels, receptors, enzymes)) EUB0000304b ADORA2B
Displacement of [3H]DPCPX from human A2BAR incubated for 60 mins by scintillation counter analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by [3H]DPCPX addition and measured after 1.5 hrs by TopCount scintillation counting method
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to human wild type A2BR expressed in CHO-K1 by schild plot analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of [3H]MRS1754 from A2BAR (unknown origin) expressed in HEK293 cells assessed as inhibition constant by competitive binding assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as inhibition constant by surface plasmon resonance assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as dissociation constant by surface plasmon resonance assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 20 Tested
Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as affinity off-rate by surface plasmon resonance assay
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to human wild type adenosine A2B receptor expressed in Expi293F cells assessed as affinity on-rate by surface plasmon resonance assay
Antagonist activity at human adenosine A2B receptor expressed in mouse NIH/3T3 cells assessed as inhibition of NECA-induced IL-6 release
Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as inhibition of cAMP production
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Antagonist activity at human adenosine A2B receptor assessed as inhibition of NECA-stimulated cAMP accumulation
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